ABSTRACT
Background: Acne vulgaris is a dermatological disorder characterised by formation of comedones and inflammatory lesions. Acne is one of the most common reason for visiting a dermatologist in early adulthood. The current line of management for mild to moderate acne is topical medications with antimicrobials and retinoids. The present study assessed the effectiveness and safety of topical combination therapy for mild to moderate acne vulgaris.Methods: An observational, prospective and comparative study conducted on newly diagnosed acne vulgaris patients who were treated with topical combination therapy. Changes in the total, inflammatory and non-inflammatory lesion counts, investigator global assessment (IGA) and dermatology life quality index (DLQI) scales were recorded to check effectiveness. Treatment emergent adverse events were recorded in suspected ADR reporting form for safety assessment.Results: Participants (n=97) were treated with three topical combination treatments either clindamycin-benzoyl peroxide (group-A), clindamycin-adapalene (group-B) or benzoyl peroxide-adapalene (group C). Majority of participants (42.3%) were treated with clindamycin-benzoyl peroxide group. Reduction from baseline of total, inflammatory and non-inflammatory lesion counts were highly significant within group comparison (p<0.001), but between group differences were not significant. Significant improvement in DLQI and IGA scores were noted in all three groups, but between group comparison showed no significant differences. All three groups were safe and well tolerated and equally improve participant’s quality of life.Conclusions: all three topical combination drugs for mild acne vulgaris had similar effectiveness in terms of reduction in acne lesions with similar safety profile.
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Abstract: The study describes method development and subsequent validation of HPTLCmethod for simultaneous estimation of paracetamol (PCM), diclofenac sodium (DCL) anddicyclomine hydrochloride (DICY) in marketed combined tablet dosage form. The drugs wereextracted from marketed tablet dosage form: Spasmodart. The separation was carried out onaluminium sheet precoated with silica gel 60 F254 using toluene: ethylacetate: methanol: formicacid (5.5:3.5:2:0.02, v/v/v/v) as a mobile phase. The spots were scanned densitometrically at266 nm wavelength for paracetamol and diclofenac sodium. The plate was then dipped in panisaldehyde reagent and spots of dicyclomine hydrochloride were scanned at 638 nmwavelength. The Rf values of paracetamol, diclofenac sodium and dicyclomine hydrochloridewere found to be 0.41, 0.71and 0.24 respectively. Calibration curves were linear in range of3250-9750ng/spot, 500-1500ng/spot and 200-600ng/spot for PCM, DCL and DICY respectively.The limit of detection (LOD) for paracetamol, diclofenac sodium and dicyclomine hydrochloridewere found to be 812.5, 125 and 50ng/spot respectively. The suitability of this method forquantitative determination of compounds was proved by validation in accordance with ICHGuidelines. Therefore this method can be applied for routine analysis of these drugs in tabletformulation.
ABSTRACT
Introduction:There is no cure for HIV/AIDS and no effective vaccine available till date. So, only prevention of transmission of HIV would be effective in significantly slowing the spread of AIDS. With this view the following study was undertaken to assess the level of awareness regarding HIV/AIDS among secondary school students and to evaluate impact of IEC among them Method:An interventional study was conducted in randomly selected 3 schools with all the class 9 and 10 students. First, students were pretested for their awareness by semi-structured questionnaire then IEC was given which include poster and intra group open discussion. Post test evaluation was conducted after 24 hours to evaluate impact of IEC. Analysis was done in Ms Excel 2007 Results:Out of 298 students, 87.58% had heard about HIV/AIDS. Only 34% knew about full form of HIV/AIDS which increased to 71% after IEC intervention. There were many myths for HIV/AIDS transmission i.e. it is transmitted by Mosquito bite 58%, Sneezing and coughing of HIV positive person 58.72% which decreased to 13%, 15% respectively. Only 34% were aware HIV/AIDS is not curable which increased to 74.83 %. These all differences were found statistically significant. (Z test of proportion was applied) Conclusion:Educational programmes are recommended to facilitate students with correct scientific knowledge regarding HIV/AIDS.
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Quinazoline derivatives have been very well known for Antihypertensive activity. Seven new Quinazoline derivatives are synthesized by three steps. Purity of compound is checked by TLC monitoring. All synthesized compounds are confirmed by UV, IR, Mass and H1NMR. All synthesized compound were screened for α1-adrenergic receptor blocking activity. Amongst all synthesized compounds 4a & 4e showed better activity.
ABSTRACT
Background: Hypertension is the commonest cardiovascular disorder posing a major public health challenge, a chronic condition of concern due to its role in causation of coronary heart disease, stroke and other vascular complications. Aim and Objectives: To assess the Cardiovascular Risk Factors in apparently healthy individuals of B.J. Medical College and Civil Hospital, Ahmedabad and to raise awareness among them. Materials and Methods : The present study was carried out on 422 (179 females, 243 males) apparently healthy individuals aged 18 to 72 years at B. J. Medical College canteen and affiliated hospital O.P.D. for a period of one month and their height, weight, BMI(Body mass index) and blood pressure were measured. Results: Number of subjects with above normal systolic blood pressure were 88, out of which 68.2% were males with p value<0.05. 38.86% persons found to be overweight (with BMI >24.99) out of which 49.39% were females and 50.61% were males. 20.85% persons had Above Normal BP (Systolic BP >139) out of which 79.5% were persons >40 yrs of age and 59.1 % were overweight (with BMI >24.99). Conclusion: Screening for the cardiovascular risk factors could be useful in detection of modifiable risk factors of cardiovascular diseases especially hypertension and obesity.