Analysis of GLUT-1, GLUT-3, and angiogenic index in syndromic and non-syndromic keratocystic odontogenic tumors

Abstract The aim of this study was to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in keratocystic odontogenic tumors associated with Gorlin syndrome (SKOTs) and non-syndromic keratocystic odontogenic tumors (NSKOTs), and to establish correlations with the angiogenic index. Seventeen primary NSKOTs, seven recurrent NSKOTs, and 17 SKOTs were selected for the study. The percentage of immunopositive cells for GLUT-1 and GLUT-3 in the epithelial component of the tumors was assessed. The angiogenic index was determined by microvessel count. The results were analyzed statistically using the nonparametric Kruskal-Wallis test and Spearman’s correlation test. High epithelial immunoexpression of GLUT-1 was observed in most tumors (p = 0.360). There was a higher frequency of negative cases for GLUT-3 in all groups. The few GLUT-3-positive tumors exhibited low expression of this protein in epithelial cells. No significant difference in the angiogenic index was observed between groups (p = 0.778). GLUT-1 expression did not correlate significantly with the angiogenic index (p > 0.05). The results suggest that the more aggressive biological behavior of SKOTs when compared to NSKOTs may not be related to GLUT-1 or GLUT-3 expression. GLUT-1 may play an important role in glucose uptake by epithelial cells of KOTs and this process is unlikely related to the angiogenic index. GLUT-1 could be a potential target for future development of therapeutic strategies for KOTs.

Estudo clínico e histopatológico de lesões centrais de células gigantes e tumores de células gigantes / Clinic and histopathological study of central giant cells lesions and giant cells tumors

Objetivo: Avaliar os aspectos clínicos e histopatológicos de um grupo de Lesões de Células Gigantes Centrais e Tumoresde Células Gigantes dos Ossos Longos, objetivando o diagnóstico diferencial entre essas lesões, bem como, correlacionaros resultados com o comportamento biológico de cada lesão. Material e Método: A amostra consistiu de oito casos de Lesão de Células Gigantes Centrais e sete casos de Tumores de Células Gigantes dos Ossos Longos, obtidos nos arquivos do Serviço de Anatomia Patológica da Disciplina de Patologia Oral de uma Universidade e do Laboratório de Patologia e Citologia Ltda. de um município, respectivamente. Os espécimes seccionados foram corados pela técnica da Hematoxilina/ Eosina (H/E) e analisados em microscopia de luz. Resultados: Similaridades marcantes foram observadas em alguns aspectos clínicos e histopatológicos, entre as lesões analisadas. Conclusão: Os resultados desta pesquisasuportam a hipótese da existência de um único processo patológico.