ABSTRACT
El síndrome antifosfolípido (SAF) fue descrito y caracterizado durante la segunda mi-tad del siglo XX inicialmente como un fenómeno protrombótico secundario en con-texto de otras enfermedades del tejido conectivo, principalmente lupus. Sin embargo, el estudio de pacientes con enfermedad primaria impulsó a distintos consensos, tan-to clínicos como de laboratorio para su correcta identificación. Entre los pacientes con SAF destaca la forma de presentación catastrófica, de baja prevalencia, pero impor-tante por su mal pronóstico, caracterizada por el compromiso de múltiples sistemas en corto tiempo. Presentamos el caso de una paciente del Hospital Clínico San Borja-Arriarán con diag-nóstico de SAF primario, que presentó en su evolución la forma catastrófica. Este caso sirve de base para una revisión del proceso diagnóstico del SAF en relación a otras patologías reumatológicas y las características propias del SAF catastrófico.
Antiphospholipid syndrome (APS) was described and characterized during the second half of the 20th century initially as a secondary prothrombotic phenome-non in the context of other connective tissue diseases, mainly lupus. However, the study of patients with primary disease prompted different consensus, both clin-ical and laboratory for their correct identification. Among patients with APS, the catastrophic presentation is of low prevalence, but important because of its poor prognosis, characterized by the commitment of multiple systems in a short time. We present the case of a patient from the San Borja-Arriaran Clinic Hospital with di-agnosis of primary APS, which presented the catastrophic form in its evolution. This case serves as a basis for a review of the diagnostic process of APS in relation to other rheumatologic pathologies and the characteristics of catastrophic APS.
Subject(s)
Humans , Female , Middle Aged , Thrombosis/etiology , Antiphospholipid Syndrome/complications , Antiphospholipid Syndrome/therapy , Tomography, X-Ray Computed , Antiphospholipid Syndrome/mortality , Antiphospholipid Syndrome/diagnostic imaging , Stroke , IschemiaABSTRACT
We developed a prospective, open study to evaluate the efficacy of chondroitin sulfate in the treatment of kneeosteoarthritis. Methodology: We studied 61 patients with primary knee osteoarthritis. They were given 800mg/day chondroitin 4-and 6- sulfate (Condrosulf, IBSA, Switzerland) for a period of three months. Patients were controlled every 30 days using the Lequesne index and the visual analogue pain scale. Medication was suspended after 90 days and patients were reevaluated 90 days later. Only Paracetamol was allowed as analgesic. Results: After 90 days a significant improvement of45 percent was observed in the Lequesne index, and 59 percent for knee pain. Once medication is suspended, the effect tends to slowly revert, with final study results significantly better than basal levels. Residual effect is better in patients under age 65 and in those with less basal radiological damage. Subjective opinion of both patient and doctor concurs with results. Conclusions: Chondroitin 4-and 6- sulfate is effective for the symptomatic treatment of knee osteoarthritis. Its effect lasts several months after drug suspension.
Subject(s)
Humans , Male , Female , Middle Aged , Mice , Chondroitin , Osteoarthritis, Knee/diagnosis , Knee/physiopathologyABSTRACT
Background: Rheumatologic diseases are common and frequently managed by primary care physicians. Aim: To assess strengths, weaknesses and self confidence of primary care physicians in the management of rheumatic diseases. Material and methods: A self assessment and anonymous questionnaire was mailed to primary care physicians of two Chilean regions. Using a 10 points Likert scale, they were asked about personal interest, undergraduate training, continuous medical education, availability of medical literature, complementary laboratory tests and consultation with a rheumatologist. Medical skills, knowledge, therapeutic approach and performance of rheumatologic procedures were evaluated under the item confidence. Results: Three hundred forty seven out of 763 physicians (45%) answered the questionnaire. Their age range extended from 25 to 75 years, 59% were male, 58% were Chilean and 74% worked in the Metropolitan region. The worst evaluated parameters were availability of literature with a score of 2.2±2, access to consultation with a rheumatologist (3.8±2.2) and to continuous medical education (4.3±2.7). Physicians had a better confidence in their knowledge (6.7±1.5) and in their therapeutic approach (6.1±1.5). The worst confidence score was for shoulder injection therapy (3.4±2.6). Continuous medical education correlated with knowledge but not with clinical skills. Conclusions: Primary care physicians perform a bad assessment of their skills in rheumatology. They have a low level of confidence in their clinical skills to perform rheumatologic procedures. Continuous medical education improves confidence in knowledge but not in skills.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Clinical Competence/standards , Physicians, Family/psychology , Primary Health Care/standards , Rheumatic Diseases/therapy , Self-Assessment , Analysis of Variance , Chile , Clinical Competence/statistics & numerical data , Physicians, Family/education , Primary Health Care/statistics & numerical data , Surveys and Questionnaires , Rheumatic Diseases/diagnosis , Rheumatology/education , Socioeconomic Factors , Statistics, NonparametricABSTRACT
Background: Systemic vasculitis are a group of heterogeneous diseases characterized by inflammation and necrosis of blood vessel walls. The etiology is not known, but geographic and environmental factors are implicated. Aim: To describe the clinical features of microscopic polyangiitis (MPA) and Wegener's granulomatosis (WG) in a Chilean cohort of patients. Patients and methods: Retrospective review of the medical records of 123 patients with the diagnosis of systemic vasculitis (65 MPA and 58 WG), seen from 1990 to 2001. The diagnosis were made based on the American College of Rheumatology and Chapel Hill criteria. Results: The mean follow-up for MPA was 15 months (1-120) and for WG, 20 months (1-120). The median age (years) at diagnosis for MPA was 61 (19-82) and WG 50 (20-82). Gender distribution was similar in both groups (male: 68percent and 57percent respectively).The main clinical features in the MPA group were renal involvement (68percent), peripheral nervous system involvement (57percent), pulmonary hemorrhage (28percent), and skin disease (32percent). In the WG group were alveolar hemorrhage (62percent), renal involvement (78percent), paranasal sinus involvement (57percent), and ocular disease (26percent). In both, creatinine levels above 2.0 mg/dl were associated with a higher mortality (p< 0.01). ANCA by immunofluorescence was performed in 56 MPA patients (75percent had pANCA, 4percent had cANCA and 21percent were ANCA negative) and in 55 WG patients (17percent had pANCA, 79percent had cANCA and 4percent were ANCA negative). Global mortality was 18percent and 17percent respectively, and the most common causes of death were infections. Conclusions: The clinical features of our patients are similar to other published data. In our WG and MPA patients the main predictor for death was a serum creatinine above 2 mg/dl.
Subject(s)
Adult , Male , Humans , Female , Middle Aged , Granulomatosis with Polyangiitis/complications , Granulomatosis with Polyangiitis/immunology , Granulomatosis with Polyangiitis/pathology , Polyarteritis Nodosa/complications , Polyarteritis Nodosa/immunology , Polyarteritis Nodosa/pathology , Chile , Follow-Up StudiesABSTRACT
Primary musculoskeletal pain consultation is high, and physicians are faced with a number of challenges. One of these is to differentiate between diseases that present similar symptoms, some potentially serious that leave sequelae and limitations, and other that are less severe but more frequent and affect patient's everyday life. Another challenge is early diagnosis in order to avoid greater damage. In order to deal with these problems, doctors must have adequate training and skills that allow them to differentiate the origin of the pain, i,e, if the pain is articular or not, or if is origin does not stem from the muscular and skeletal system. Diagnosis must also include if manifestations are localized or generalized, axial or peripheral, inflammatory or non inflammatory, acute or chronic; if the manifestation is a mono, oligo or polyarthropathy. Together with this, physicians must be aware of the extraskeletal manifestations of rheumatic diseases, such as general manifestations or involvement of diverse systems that are fundamental when diagnosing inflammatory rheumatisms. Moreover, clinical doctors must know how to used and correctly interpret the studies of articular fluid, general and correctly interpret the studies of articular fluid, general and immunological laboratory, and images, always oriented to the patient's clinical manifestation. Once these parameters have been defined, they must be syndromatically sorted in order to prepare a specific diagnosis and consequently offer the patient the most adequate pharmacological and non pharmacological treatment for each case.