Postmortem examination cases of cyanide poisoning A biological hazard.

Hydrocyanic acid and various cyanides are relatively common poisons both in suicide, accident and occasionally homicide. Acute poisoning with cyanide is most often self administered as the swift and sure action is generally known. Accidental poisoning from inhalation of vapours due to fires in buildings or by the free gas liberated from some commercial processes is also known to occur. The preparations are rarely used with homicidal intent. Whatever be the manner of poisoning, in medical settings the persons involved in postmortem examination of cases of death of cyanide poisoning are exposed to significant degree of cyanide remaining in the body cavities and tissues of the deceased. This risk is not only for the persons attending postmortem examination but also for the first respondents like police, rescue persons and also persons extending emergency care both outside and within hospital. Hydrocyanic acid is rapidly absorbed from all mucous surfaces and even from unabraded skin .Hence attending a case of cyanide poisoning involves a hazard of inhalation of cyanide gas from the victim The hazards involved in such situations are briefly reviewed.

Coagulation abnormalities in systemic lupus erythematosus.

Coagulation profile was studied in 55 patients of systemic lupus erythematosus (SLE). Abnormal kaolin clotting time (KCT) was observed in fewer patients (12.9%) as compared to abnormal Russel's viper venom time (RVVT, 20.4%) or activated partial thromboplastin time (APTT, 32.7%). Prolonged prothrombin time (PT), observed in 7.3 per cent patients was not found to be a sensitive test for lupus anticoagulant (LAC). The correction of RVVT and KCT on addition of inosithin suggested a deficiency of platelet lipid factor in these patients. The initial value of uncorrected KCT in patient's plasma did not correlate with the amount of inosithin required for neutralisation. Occurrence of thromboembolic events was significantly associated with prolonged KCT. No other clinical feature showed significant association with any coagulation abnormality.