ABSTRACT
Objetivos: las enfermedades cardiovasculares constituyen la principal causa de muerte en el mundo. Se ha identificadoa la hiperhomocisteinemia como uno de los factores de riesgo modificables para ésta enfermedad. El objetivo delestudio es determinar la asociación entre la hiperhomocisteinemia y la enfermedad cerebrovascular (ECV) porenfermedad de pequeños vasos (EPV). Material y Métodos: se incluyeron 101 historias clínicas de pacientes conECV admitidos durante 5 meses de manera consecutiva. Se excluyeron pacientes con ECV cardioembólica. Losinfartos se clasificaron en aquellos debidos a EPV y a otros subtipos de infarto no cardioembólico (NoEPV). Secompararon los niveles medios de homocisteína plasmática entre ambos grupos. Se estudió la relación entre losfactores de riesgo cardiovascular incluida la hiperhomocisteinemia; y la EPV a través de un análisis bivariadoy multivariado para factores de confusión.
Objectives: Hyperhomocysteinemia has been described as a risk factor for coronary disease and ischemic stroke. The aim of this paper is to determine the association between hyperhomocisteinemia and ischemic stroke caused by small vessels disease (SVD) in a group of non-cardioembolic stroke patients. Material and methods: One hundred and one clinical records of stroke patients admitted during 5 months were included. Stroke patients with a cardioembolic etiology were excluded. Stroke was classified into infarctions due to SVD and other non-cardioembolic infarctions (non-SVD) by using Adams criteria. We compared the levels of serum homocysteine between both groups using the T student test for independent samples. Bivariate and multivariate analyses for confounding factors were performed.