ABSTRACT
Objective:- Murraya koenigii commonly known as curry patta is used in the ancient medicine for curing different ailments. The aim of the present work is to estimate total phenolic content found in the leaves of Murraya koenigii. Method:- Total phenolic content of Murraya koenigii was assessed by Folin-Ciocalteu reagent by using gallic acid as calibration standard. Result:- The total phenolic content was measured by Folin-Ciocalteu was found to be 5.32. Conclusion:- From the findings it may be concluded that this drug may find use in diabetes and liver related problems.
ABSTRACT
In the present study, we have reported the synthesis of some novel heterocyclic derivatives comprising imidazole and 1,3,4-thiadiazole containing moiety. Imidazothiadiazoles are of interest because of their diverse biological activities and clinical applications. Reactions of biphenyl carboxylic acid with thiosemicarbazide in the presence of phosphorous oxychloride resulted in biphenyl containing 2-amino-1,3,4-thiadiazole which is then further subjected to condensation with α-bromoarylketone under reflux in dry ethanol. The structures of the newly synthesised compounds were characterized by various spectral techniques and screened for antibacterial activity against strains of Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis, and antifungal activity against Candida albicans, Saccharomyces cerevisiae and Aspergillus niger. The compounds exhibited moderate to good activity when compared with standards.