ABSTRACT
Backgroung: Diabetes Mellitus is a global problem caused by the deficiency of Insulin secretion either absolute or relative. Treatment options are Insulin and oral glucose lowering drugs. Current study was designed to find out the glucose lowering properties of S-allylcysteine a garlic derivative sulfur containing amino acid
Objective: To compare blood glucose lowering effects of S-allylcysteine with gliclazide in diabetic rat model
Study Design, Place and Duration: This 3 months animal study was carried out in animal house of ISRA University Hyderabad from August 2014 to Oct 2014
Material and Methods: 32 Male Wistar Rats were randomly divided into 4 equal groups A, B, C and D after selection through non-probability purposive sampling. Group A and B served as positive and negative controls respectively. Diabetes was induced in Group B, C and D by injecting alloxan at the dose of 120 mg/kg according to the weight of rats. Rats in group C and D were treated with S-allylcysteine [150 mg/kg], gliclazide [5 mg/kg] respectively. Random blood sugar levels of all groups were measured after weeks 1, 2 and 3. The data was analyzed by SPSS version 21.0
Results: Blood glucose levels after 2[nd] and 3[rd] week were 264.3 +/- 43.16 vs. 218.75 +/- 36.38 [p=0.0001] for SAC and 229.0 +/- 89.87 vs. 241.0 +/- 48.19 mg/dl for Gliclazide [p=0.001] while at the end of 3[rd] week results for two control groups were non-significant statistically [p-0.07 and0.09]
Conclusion: It is concluded that S-allylcysteine possess blood glucose lowering properties that are comparable to gliclazide
ABSTRACT
Background: Syzygium aromaticum is commonly known as clove. It is being used since centuries for different purposes in different parts of the world
Objective: To explore the effects of Syzygium Aromaticum, its effects on the liver enzymes
Methodology: This Randomized Control Trial was conducted in Postgraduate Laboratory and Animal House of ISRA University. 30 Healthy Rabbits weighing 2kg on average were divided into 3 equal groups. Group A was taken as control group having no intervention while group B was given paracetamol 500mg BD for 10 days followed by Syzygium Aromaticum powder 100mg BD for next 10 days. Group C was given paracetamol 500mg BD and Syzygium Aromaticum powder 100mg BD for 20 days. Blood samples were taken from ear lobes through 24 gauge canula for liver enzymes at days 1, 10 and 20 and analyzed in ISRA Laboratory. Mean and standard deviation were calculated and p-value <0.05 was taken as significant. The data was entered and analyzed by using SPSS version 16. Results: There was no rise in liver enzymes in group A at any stage of the study. Liver enzymes ALT, AST, GGT, ALP and LDH markedly increased in group B in initial 10 days but declined in next 10 days. There was no significant rise in liver enzymes in group C at any level of the study. Conclusion: Syzygium aromaticum is an effective natural hepatoprotective agent
ABSTRACT
To investigate blood glucose regulaitng effects of Catharanthus Roseus [C.roseus] and Nigella sativa [N.sativa] in alloxan induced diabetic rats. Experimental study. Animal house Isra University Hyderabad. From April to Novermber 2013. 50 male rats were housed at normal température, 12 hour dark - light cycle with free access to chow and water. A single intraperitoneal bolus of alloxan [120 mg/kg] was given to induce diabetes mellitus. Glimepiride, C. roseus and N. Sativa were administered at doses of 0.1 mg/kg, 125 mg/kg and 50 g/kg respectively. Data was analyzed on SPSS version 21.0. Significant P - value was defined at