ABSTRACT
Objective To explore the prognostic influence of combination therapy with mild hypothermia and edaravone for acute cerebral infarction.Methods Two hundred and forty-five cases of diagnosed as acute cerebral infarction within 72 hours of onset were randomly divided into four groups according to the doctor visiting time.All the groups were treated with routine drugs.Combined therapy group (65 cases ) was treated with mild hypothermia combined with edaravone.Mild hypothermia group (59 cases ) was treated with local mild hypothermia.Edaravone group (58 cases) was treated with edaravone.Control group (63 cases) was only treated with routine drugs.The European Stroke Scale (ESS) score was performed before treatment,30 days after treatment.The activity of daily living (ADL) scores were evaluated before treatment,30 and 90 days after treatment.Results ESS scores were (45.22 ± 16.94),(46.88 ± 22.54),(47.13 ± 10.92),(46.94 ± 16.41 ) scores before treatment in combined therapy group,mild hypothermia group,edaravone group,control group respectively.ALD scores were (20.54 ± 14.65 ),(20.94 ± 10.93),(21.83 ± 14.71),(23.61 ± 18.91 ) scores before treatment in combined therapy group,mild hypothermia group,edaravone group,control group respectively.There were no differences in ESS and ADL scores before treatment among the groups.ADL scores were higher 30,90 days after treatment in combined therapy group [(59.57 ± 30.99),(74.46 ± 25.61) scores] than those in mild hypothermia group [(43.91 ±27.61),(58.13 ±26.62) scores) and control group [(34.58 ±27.75), (45.56 ±26.10) scores] (P ＜ 0.05) and higher after 90 days treatment than that in edaravone group [(62.83 ± 28.74) scores] (P ＜ 0.05 ).ESS scores 30 days after treatment in combined therapy group [(72.24 ± 14.54) scores] were higher than those in mild hypothermia group [(65.88 ± 17.76) scores],edaravone group [(65.27 ± 18.02) scores],control group [(60.62 ± 14.97) scores] (P ＜ 0.05 ).The effectiveness in combined therapy group [63.08％ (41/65)] was higher than that in mild hypothermia group [42.37％(25/59)],edaravone group [41.38％ (24/58)] and control group [23.81％ ( 15/63 )] ( P ＜ 0.05 ).The mortality rate in combined therapy group [9.23 ％ (6/65)] was lower than that in mild hypothermia group[10.17％(6/59)],edaravone group[12.07％(7/58 )] and control group [12.70％ (8/63)],but there was no significant difference (P ＞ 0.05 ).Conclusion The combination therapy with mild hypothermia and edaravone can improve the prognosis of acute cerebral infarction.
ABSTRACT
Objective To explore the therapeutic effects of local mild hypothermia for acute cerebral infarction(ACI). Methods 99 hospitalized patients with ACI form January 2006 to July 2009 were randomly divided into mild hypotherrmia group(therapy group,n =52) and control group(n =47). All the patients were treated with routine medication,while those in therapy group patients were aslo treated local mild hypothermia. Before treatment,the 10th and 30th day after treatment ,the neurological deficits and activity of daily living(ADL) were evaluated according to European Stroke Scale(ESS) and Barthel Index respectively,and were evaluated according to Barthel Index on the 90th day. Results On the 10th and 30th day the increase rate of ESS was evaluated. On the 30th day,there was significant difference between the therapy group (74. 4 ± 13. 8) and controll group (65.0 ± 17.6) (t = 3. 121,P ＜ 0.01).On the 10th and 30th and 90th day the improvement of ADL was observed. The increase rate of ADL was(39.2 ±32. 2,59.3 ±29. 7,64. 0 ±31.5) in the therapy group and(23.9 ± 19. 8,49. 3 ±27. 3,56. 0 ± 30. 1) in the controll group (t = 2.611 ～ 2.73.6, P ＜ 0.05 ～ 0.01). The effective rate of the therapy group was 78. 8%, and the effective rate of the controll group was 46. 7%. There was significant difference between the therapy group and the controll groups (x~2 = 10. 953, P ＜ 0.01). Conclusion The local mild hypothermia is more effective than those in the controll group for ACI.