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OBJECTIVE:To establish a HPLC method for determining the concentration of ornidazole in mother's milk METHODS:Stationary phase was Nova-Pak C8 column Mobile phase was methanol-water(30∶70) Samples were precipita_ted by acetonitrile without being extracted with organic solvent RESULTS:The endogenous substances in milk did not interfere with the determination of ornidazole The calibration curve was linear within the concentration range of 2 0～30 0?g/ml,r=0 9 997;the limit of detection was 0 49?g/ml;the average recovery was(99 67?0 54)%,and the within-day and between-day RSDs did not exceed 2 5% and 2 1%,respectively CONCLUSION:The method is simple,quick,accurate,sensitive,precise and usable for pharmacokinetic study of ornidazole in mother's milk
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0 05) CONCLUSION:The two products of valaciclovir tablet are bioequivalent
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Objective: To study the effect of XRK on mice's acute inflammation. Methods:The three XRL groups were fed on XRK of high, middle and low dosage, the positive group was fed on mezolin, and the control group was fed on distilled water. All groups were fed for three days, once per day. 30 minutes after the last treatment, Xylene (0.05 ml) was spreaded on mice's right ear in two sides, 15 minutes later, mice were put to death and its two ears were cut in same area, then weighed, calculated the swelling degree of its ears. Results: ① The swelling degrees in the three XRL groups were all lower significantly than that in the control group ( P
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OBJECTIVE:To observe the effects of Xiaoer Reganning oral liquid(XRN) on clinical symptoms and signs of children with acute upper respiratory tract infections.METHODS:161 children with acute upper respiratory tract infections were randomly divided into three groups.The patients were treated with XRN(XRN group,60 cases),Shuanghuanglian oral liquid(SHL group,41 cases) and Wei C Yingqiao granules(WCG group,60 cases),3～4 times every day for 3 days.The changes of clinical symptoms of coughing rhinorrhea,lassitude,anorexia and dyssomnia,and signs of pharyngeal congestion and tonsillar swelling were studied on the patients before and after treatment for three days,and the results of three groups were compared.RESULTS:The improvement of the clinical symptoms and signs in XRN group was better than that in the control groups(P
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OBJECTIVE:To optimize the formula of Ginkgo flavone tablets.METHODS:The effects of dextrin,CMS-Na,microcrystalline cellulose and L-HPC on the quality of Ginkgo flavone tablets were studied.RESULTS:The results showed that the optimum formula was 5% L-HPC Ginkgo flavone.Tablet prepared with this optimum formula was much better in terms of disintegrantion.CONCLUSION:The formula is reasonable and the preparation technic simple.The prepared tablets are suitable for clinical use.