ABSTRACT
The bronchoconstricting and bronchodilating divisions of the autonomic nervous system control airway caliber of lungs. Parasympathetic hyperactivity in asthmatics eventuates in broncho-constriction. Sympathetic activity increases to combat this but fails to control bronchoconstriction due to negligible innervations of the airway smooth muscles although it causes vasoconstriction of blood vessels. In this study the effects of autonomic function test for sympathetic division were seen on selected patients and controls. Our results indicate sympathetic hyperactivity or an increased alpha-adrenergic input in asthmatics.
Subject(s)
Adult , Asthma/physiopathology , Bronchial Hyperreactivity/physiopathology , Bronchoconstriction/physiology , Electrocardiography/methods , Female , Heart Rate/physiology , Humans , Male , Sympathetic Nervous System/physiopathologyABSTRACT
The modern living lifestyle is known to produce various physical and psychological stresses and subject the individual to produce oxidative stresses as well. The aim of this study has been to assess the effect of yogic breathing exercises (pranayama) on the oxidatives stress. The study group consisted of 30 young male volunteers, trained for the purpose of this study and an equal number of controls were used. The free radicals and Super oxide dismutase levels were measured before the study and at the end of the study. The free radicals were decreased significantly in the study group but the SOD was increased insignificantly as compared to the control group. Yogic breathing exercises not only help in relieving the stresses of life but also improve the antioxidant status of the individual. An improvement in the antioxidant status is helpful in preventing many pathological processes that are known with impaired antioxidant system of body.
Subject(s)
Adolescent , Adult , Antioxidants/metabolism , Free Radicals/blood , Humans , Life Style , Lipid Peroxidation , Male , Oxidative Stress/physiology , Superoxide Dismutase/blood , YogaABSTRACT
The effects of cigarette and bidi smoking on pulmonary function tests have been studied in 90 healthy males from North India Forced vital capacity (FVC), peak expiratory flow rate (PEFR), forced expiratory volume in 1 sec (FEV) were determined in 30 nonsmokers (as control group), 30 cigarette smokers and 30 bidi smokers. All the above pulmonary function parameters were found to be lower among smokers as compared to nonsmokers. Moreover, the decrease in the pulmonary function tests was greater in cigarette smokers as compared to bidi smokers.
Subject(s)
Adult , Humans , Lung/drug effects , Male , Respiratory Function Tests , Smoking/adverse effectsABSTRACT
The present study was conducted on 40 male and 10 female students appearing for the 1st MBBS examination. Two readings of pulse rate, blood pressure and electro cardiogram were taken viz 6 months (control) and 10 minutes prior to the examination. A significant increase was seen in the pulse rate and blood pressure readings before the examination as compared to the control readings. However, no significant change was observed in electro cardiographic recordings.
Subject(s)
Adolescent , Adult , Blood Pressure/physiology , Educational Measurement , Female , Humans , Male , Pulse/physiology , Stress, Psychological/physiopathology , Students, Medical/psychologyABSTRACT
A study was carried out to determine the involvement of dopaminergic system in opioid-induced cardiovascular responses in the dogs. The study population consisted of 32 mongrel dogs of either sexes. The results show that morphine given in small dose (2 mg/kg I.V.) causes significant fall in blood pressure. The results also show that there is involvement of dopaminergic system in opioid-induced vasomotor responses in dogs. Partial blockade of the parenterally induced hypotensive response of morphine by haloperidol given centrally induced hypotensive responses of morphine by haloperidol given centrally in doses, which are too low to be effective by the peripheral route, strongly favours the involvement of central dopaminergic system in the morphine-induced hypotensive responses. The results also show that the hypotensive response of morphine was almost completely blocked after naloxone pretreatment by central route.
Subject(s)
Animals , Blood Pressure/drug effects , Central Nervous System/drug effects , Dogs , Female , Haloperidol/pharmacology , Male , Morphine/antagonists & inhibitors , Naloxone/pharmacology , Receptors, Dopamine/drug effectsABSTRACT
Angiotensin II is produced physiologically in response to renal ischaemia due to hypotension. It's effect on heart rate and blood pressure were studied on anaesthetised mongrel dogs. Angiotensin II was given in different concentrations, by intravenous, intraarterial in carotid artery and intracerebroventricular routes. Cervical vagotomy and carotid sinus inactivation were done is abolish the reflex inhibition produced by baroreflexes. Rise of B.P. is due to mainly peripheral vasopressor action of angiotensin II, however it is shown to have a central component as well. This is demonstrated by ICV injections. Tachycardia due to central action is also demonstrated in this study. Both actions are significant. This study also confirm the earlier findings that angiotensin II passes the blood brain barrier.