ABSTRACT
A carcinoma arising within a fibroadenoma is an unusual occurrence, with only a little over 100 reported cases. The purpose of this report is to increase the awareness of this entity and to discourage the practice of rendering a diagnosis on gross examination of the tumor. We are reporting a case with two distinct primary tumors within the same breast, one of which was arising within the fibroadenoma. Only two such cases have been previously reported.
Subject(s)
Breast Neoplasms/pathology , Carcinoma in Situ/pathology , Carcinoma, Ductal, Breast/pathology , Carcinoma, Lobular/pathology , Female , Fibroadenoma/pathology , Humans , Mastectomy, Modified Radical , Middle Aged , Neoplasms, Multiple Primary/pathologySubject(s)
Female , Humans , Middle Aged , Mixed Tumor, Mullerian/pathology , Ovarian Neoplasms/pathologyABSTRACT
In this study, and attempt was made to differentiate between follicular neoplasms of the thyroid using an immunoperoxidase staining technique for detection of ceruloplasmin. 54 histologically proved benign and malignant thyroidal lesions were selected. The staining for ceruloplasmin was consistently positive in follicular carcinoma and negative in follicular adenoma.
Subject(s)
Adenoma/chemistry , Ceruloplasmin/analysis , Humans , Thyroid Neoplasms/chemistry , Biomarkers, Tumor/analysisABSTRACT
Case histories of three male patients diagnosed as idiopathic retroperitoneal fibrosis either on autopsy or following intra-operative biopsy are reported. Two of them were in the 5th decade and one aged 22 yrs. All of them presented with features of urinary tract obstruction and renal failure. The obstruction was detected either by ultrasonography or following ascending pyelogram. One of them underwent peritoneal dialysis but later on died of sudden cardiac arrest. The remaining two underwent surgery, during which a biopsy was taken. Histological examination in all the three patients revealed fibroblastic proliferation and mononuclear cell infiltration. Features of chronic periaortitis were also found in the autopsy specimen of descending aorta of the first patient. Both the elderly patients had aortic atherosclerosis which is suspected to be the etiological factor for fibrosis. However in the young male patient intense eosinophilic infiltrate was observed in biopsy material pointing towards 'hypersensitivity' reaction as a cause for fibrosis.
Subject(s)
Adult , Humans , Kidney Failure, Chronic/etiology , Male , Middle Aged , Retroperitoneal Fibrosis/complications , Ureteral Obstruction/etiologySubject(s)
Adult , Biopsy, Needle , Carcinoma, Papillary/pathology , Female , Humans , Pancreatic Neoplasms/pathologyABSTRACT
The fine needle aspiration cytology (FNAC) and ultrasound radiologic features of a solitary retroperitoneal angiofollicular lymph node hyperplasia (AFLNH), hyaline vascular type are described. Based on a combination of the two, this diagnosis can be suggested in the differential diagnosis of a retroperitoneal mass.
Subject(s)
Adolescent , Biopsy, Needle , Diagnosis, Differential , Castleman Disease/pathology , Humans , Male , Retroperitoneal SpaceABSTRACT
Lymph-node aspirates performed over ten years numbering 1,555 showed 8.2 percent of metastatic tumors. Of these, only six percent were metastatic melanomas. Clinical diagnosis was made in three cases. Melanin in the cells made the diagnosis easy. But even in the absence of the pigment as in two amelanotic melanomas, the cytologic features were characteristic.
Subject(s)
Adolescent , Adult , Aged , Biopsy, Needle , Cytodiagnosis , Female , Humans , Lymph Nodes/pathology , Lymphatic Metastasis , Male , Melanoma/diagnosis , Middle AgedABSTRACT
Ultrasonography (US) remains underutilized as a guidance tool for performing fine needle aspiration cytology (FNAC) mainly because of a lack of understanding and experience in this technique. We describe here our experience in performing 346 FNACs. In our opinion, US guided FNACs are highly accurate and safe procedures which can be done on an out-patient basis, with routinely available equipment.
Subject(s)
Biopsy, Needle , Cell Biology , Humans , India , Neoplasms/pathology , Sensitivity and Specificity , UltrasonographyABSTRACT
Cervicofacial actinomycosis is today a rare disease in our country. Isolated actinomycotic neck masses are extremely rare. A case of young man with an isolated midcervical tumour like actinomycotic granuloma without sinuses or discharging granules is reported here.
Subject(s)
Actinomycosis, Cervicofacial/diagnosis , Adult , Combined Modality Therapy , Granuloma, Plasma Cell/diagnosis , Humans , MaleABSTRACT
One hundred and twelve cases of cervical pathology (58 paraffin sections and 54 cervical smears) were assessed by PAP technique and 30 cases by indirect immunofluorescent technique. Forty-two normal cervical smears from the age matched controls were stained by indirect immuno-fluorescent technique. HSV-2 antigen was detected by PAP method in 86 out of 112 cases (78.57%) i.e. 50/55 squamous cell carcinoma, 13/13 carcinoma in situ, 11/15 severe dysplasia, 3/4 moderate dysplasia and 9/16 mild dysplasia. The amount of antigen was maximum in squamous cell carcinoma and decreased in carcinoma in situ, severe, moderate and mild dysplasia in descending order. Three cases of adenocarcinoma cervix were negative. Only one case out of 42 controls was positive. HSV-2 antigen was detected by an indirect IF technique in 8/9 squamous cell carcinoma, 2/3 carcinoma in situ, 3/7 dysplasia, O/1 adenocarcinoma and 4/10 inflammatory cases. The above findings support the association between HSV-2 and squamous cell carcinoma cervix, as well as carcinoma in situ which is statistically significant.