ABSTRACT
Objectives: We sought to determine the effects of the delayed start protocol with gonadotropin-releasing hormone [GnRH] antagonists in poor responders undergoing in vitro fertilization [IVF]
Methods: This randomized clinical trial was conducted during a 15-month period from April 2014 to July 2015 in clinics in Shiraz, Iran. total of 42 poor responders with primary infertility were randomly assigned to the controlled ovarian stimulation group utilizing the delayed start protocol [n = 21] or the traditional group [n = 21] using GnRH antagonist, Cetrotide. The primary endpoint was the number of patients undergoing oocyte pick-up, implantation, and the rate of pregnancy
Results: The baseline characteristics of the two study groups were comparable including age, infertility duration, and body mass index. The number of follicles measuring > 13 mm in diameter [p = 0.057], retrieved oocytes [p = 0.564], mature metaphase II oocytes [p = 0.366], embryos [p = 0.709], and transferred embryos [p = 0.060] were comparable between the two groups. The number of patients undergoing oocyte pick-up [p = 0.311], the rates of implantation [p = 0.407], and pregnancy [p = 0.596] were also comparable between the two groups
Conclusions: The delayed start protocol was not associated with better conception results or cycle outcomes in poor responders with primary infertility undergoing IVF cycles