ABSTRACT
Background: oral lichen planus is a common mucocutaneous disorder with unknown etiology. While current data suggest that oral lichen planus is a cell-mediated disease, differential diagnosis of this disease and oral lichenoid lesions is very problematic, both clinically and histopathologically. This study aimed to compare immunohistochemical features of these similar diseases
Methods: this was a descriptive-analytic study in which formalin-fixed and paraffin-embedded tissue sections of 30 oral lichen planus and 30 oral lichenoid lesions were immunohistochemically analyzed for number and distribution of IgG+ cells. A standard biotin-streptavidin procedure after antigen retrieval was used. Data were analyzed in SPSS software using Mann-Whitney U test
Results: there were some significant differences in distribution of IgG+ cells among different locations in oral lichen planus and also in oral lichenoid lesions separately; but the differences between distribution of IgG+ cells between the two groups of oral lichen planus and oral lichenoid lesions were not significant
Conclusion: there was no significant difference in number and distribution of IgG+ cells between the two groups. So, this study can suggest that location of IgG is similar in samples of oral lichen planus and oral lichenoid lesions and consequently, this marker cannot help us differentiate them from each other. Other markers can be analyzed in further studies in order to find an appropriate distinguisher between the two lesions
ABSTRACT
Recurrent aphthous stomatitis [RAS] is an oral mucous lesion in patients with no other signs of disease. Investigators have always notified the role of immune system especially humoral immunity in aphthous immunopathogenesis. The aim of this case-control study was to measure amount of serum immunoglobulins [A, G, M] and complement components [C3, C4] in patients with RAS and to evaluate any relation between differences in these factors and pathogenesis of it.Immunoglobulins [A, G, M] and complement components [C3, C4] of 50 patients with RAS were measured by using single radial immunodifrusion technique [SRID T]. The results were compared with immunoglobulins [A, G, M] and complement components [C3, C4] of 50 healthy people whom were similar in age and sex with the patients of case group. Results showed that the patients group had higher level of IgA and IgM while serum IgG was similar in both groups. The C3 was lower in aphthous patients while no significant difference was found in amount of C4. The sex had no significant effect on serum level of measured factors. The results show that the humoral immunity reaction has an important role in immunopathogenesis of RAS. This humoral response might occure as a result of cellular immunity reaction
ABSTRACT
"Recurrent Aphthous Stomatitis" is an ulcer that appears in the Oral mucosa in the form of painful and often recurrent ulcers. Its prevalence is 10 to 20 percents. And in some of the selected groups such as students, its prevalence is up to 50 percents. Its appearance in female is more than male. No single reason has been recognized for this disease. Some of sources have referred to the relation of this disease with stress. The purpose of this study was to survey the role of stress as one of the factors that create recurrent aphthous stomatitis. This is a case-control study, in this study 61 patients with aphthous stomatitis that had been referred to the oral medicine department of Isfahan university and affiliated clinics were examined. 61 patients were selected from two sexes randomly. Control group was consisted of the siblings of the patients who had been referred and selected randomly. After patient justification, Diagnosis and attestation of the professor, the "Standard questionnaire for measuring stress" in the name of "Klementz and Raberts" was completed by the patients and control group. The information was analyzed statistically through T-Test. The obtained information indicated that the average of stress mark in case and control group was 384 and 249 respectively. T-Test indicated that there was a significant difference between stress mark in two case and control groups [P<0.05]. The average age for the patients who suffered from recurrent aphthous stomatitis is 24 years old and the average age for healthy persons is 24 as well. Prevalence of recurrent aphthous stomatitis in people with psychological - mental problems was more than healthy people considerably. There was a significant difference between aphthous stomatitis and stress in case and control groups