ABSTRACT
Statement of the Problem: Lichen planus disease is a chronic inflammatory lesion without a known etiology. Recent studies have indicated the role of vitamin D on immune system and proposed its anti-inflammatory effects
Purpose: This study aimed to compare vitamin D serum levels in patients with oral lichen planus and healthy subjects
Materials and Method: In this case.control study, 18 patients suffering from oral lichen planus referred to the Department of Oral Medicine, Tabriz Faculty of Den-tistry were chosen as the case group and 18 healthy people were chosen as the con-trol group. A 5-mL blood sample was taken from all subjects and the subjects' vitamin D serum levels were assessed with a vitamin D total [25-hydroxy vitamin D] kit by employing the electrochemiluminescence technique. The results were analyzed and compared by using SPSS17 statistic software. p< 0.05 was considered statistically significant
Results: The mean vitamin D level in serum of patients with oral lichen planus was 30.7+/- 20.38ng/ml and in healthy subjects was 36.45 +/- 15.33ng/ml, the difference was not statistically significant [p= 0.346]
Conclusion: The difference between the level of vitamin D in the serum of patients suffering from oral lichen planus and healthy individuals was not significant
ABSTRACT
Objectives: Saliva contains alkaline phosphatase [ALP]-a key intracellular enzyme related to destructive processes and cellular damage-and has buffering capacity [BC] against acids due to the presence of bicarbonate and phosphate ions. Smoking may have deleterious effects on the oral environment due to pH changes which can affect ALP activity. This study aimed to evaluate the salivary pH, BC and ALP activity of male smokers and healthy non-smokers
Methods: this retrospective cohort study took place between August 2012 and December 2013. A total of 251 healthy male non-smokers and 259 male smokers from Hamadan, Iran, were selected. Unstimulated whole saliva was collected from each participant and pH and BC were determined using a pH meter. Salivary enzymes were measured by spectrophotometric assay
Results: mean salivary pH [7.42 +/- 0.48 and 7.52 +/- 0.43, respectively; P = 0.018] and BC [3.41 +/- 0.54 and 4.17 +/- 0.71; P = 0.001] was significantly lower in smokers compared to non-smokers. Mean ALP levels were 49.58 +/- 23.33 IU/L among smokers and 55.11 +/- 27.85 IU/L among non-smokers [P = 0.015]
Conclusion: significantly lower pH, BC and ALP levels were observed among smokers in comparison to a healthy control group. These salivary alterations could potentially be utilised as biochemical markers for the evaluation of oral tissue function and side-effects among smokers. Further longitudinal studies are recommended to evaluate the effects of smoking on salivary components
ABSTRACT
Tobacco smoking is one of the most important risk factors for the development of oral mucosal lesions such as leukoplakia and hairy tongue. Controversy exists in the literature, however, about the prevalence of oral lesions in smokers. The aim of this study was to evaluate oral lesions in male smokers compared with nonsmokers in Hamadan. A total of 516 male participants were assessed, 258 of whom were smokers and 258 of whom were healthy nonsmokers. The prevalence of lesions was evaluated by clinical observation and biopsy. We found that the most prevalent lesions among smokers were gingival problems and coated tongue; smokers had significantly more lesions than did nonsmokers. Malignant and premalignant lesions were found in a higher age range. Among all participants in our study, we found a large number of oral mucosal lesions in smokers that had a strong correlation with smoking. Dental services need to implement care and health education for smokers to promote health.
Subject(s)
Humans , Male , Biopsy , Health Education , Leukoplakia , Mouth , Prevalence , Risk Factors , Smoke , Smoking , Tongue, HairyABSTRACT
Tobacco smoking is one of the most important risk factors for the development of oral mucosal lesions such as leukoplakia and hairy tongue. Controversy exists in the literature, however, about the prevalence of oral lesions in smokers. The aim of this study was to evaluate oral lesions in male smokers compared with nonsmokers in Hamadan. A total of 516 male participants were assessed, 258 of whom were smokers and 258 of whom were healthy nonsmokers. The prevalence of lesions was evaluated by clinical observation and biopsy. We found that the most prevalent lesions among smokers were gingival problems and coated tongue; smokers had significantly more lesions than did nonsmokers. Malignant and premalignant lesions were found in a higher age range. Among all participants in our study, we found a large number of oral mucosal lesions in smokers that had a strong correlation with smoking. Dental services need to implement care and health education for smokers to promote health.