ABSTRACT
Background: Considering the difficulties, adverse effects and unsuitable response to commonly used drugs; it is essential to find an alternative, particularly local treatment for cutaneous leishmaniasis [CL]
Objective: Determination of efficacy of topical paromomycin [Paromo-U ointment] against CL caused by L.major in mouse model
Patients and Methods: Skin lesions were created 1 to 3 months after inoculation of L.major promastigotes to the base of tail of small, white mice [Outbreed]. Then the mice were randomly divided to three groups including interventional [Treatment by Paromo-U], control 1 [Treatment by urea] and control 2 [Treatment by distilled water] groups. The mice were treated topically twice a day for 8 weeks
Results: The mean lesion diameter of the lesions prior to treatment in interventional and control groups [Urea and distilled water] were measured 10.9, 5.9 and 6.0 mm respectively and changed to 4.0, 12.7 and 14.3 mm 8 weeks after treatment. No Leishman bodies were observed within the lesions of interventional group, whereas they were seen in all control groups
Conclusion: Paromo-U ointment was effective in the treatment CL caused by L.major in mouse model