ABSTRACT
An unusual case of phototoxic reaction caused by clarithromycin is being presented here as it is not reported in medical literature.
Subject(s)
Adult , Anti-Bacterial Agents/adverse effects , Clarithromycin/adverse effects , Dermatitis, Phototoxic/etiology , Humans , MaleABSTRACT
The effect of intracerebroventricular T4 on certain hypothalamic i.e., POA and VMN and cortical i.e., HPC and CO loci was investigated by recording their electroencepgraphic activity after chronic implantation of cannulae and bipolar electrodes in ten male dogs. Recordings were made for two hours after the microinjection. The predominant pattern of EEG activity was a synchrony of brain waves in all derivations except for POA where biphasic desynchronization-synchronization was observed. Final synchrony suggest refractoriness of these loci to T4 which might be playing a protective role.
Subject(s)
Animals , Blood-Brain Barrier , Brain/drug effects , Cerebral Ventricles , Dogs , Electrodes, Implanted , Electroencephalography , Injections, Intraventricular , Male , Receptors, Thyroid Hormone/drug effects , Thyroxine/pharmacokineticsABSTRACT
The effect of ICV administered TSH on Brobeck's thermostatic hypothesis was evaluated by recording chronological changes in electrical activity of precise loci (POA, VMN and CO) coupled by rectal temperature changes in dogs. The study revealed 1. TSH action on thermoregulation is biphasic in nature. 2. This action of TSH is not an independent act but depends on the reaction of satiety centre.
Subject(s)
Animals , Appetite Regulation/physiology , Body Temperature , Body Temperature Regulation/physiology , Cerebral Cortex/physiology , Dogs , Electroencephalography , Injections, Intraventricular , Male , Preoptic Area/physiology , Thyrotropin/administration & dosage , Ventromedial Hypothalamic Nucleus/physiologyABSTRACT
Electroencephalographic activity (EEG) of pre-optic area (POA) was recorded after intracerebroventricular (ICV) microinjection of thyroxine (T4) and thyrotropin (TSH) in conscious male dogs. Recordings were made for two hours following microinjections. Biphasic responses with increased amplitude were observed in both the treatments, but chronologically the responses obtained with T4 & TSH were opposite to each other.
Subject(s)
Animals , Dogs , Electroencephalography/drug effects , Injections, Intraventricular , Male , Preoptic Area/drug effects , Thyrotropin/administration & dosage , Thyroxine/administration & dosage , Time FactorsABSTRACT
The effect of intraventricularly administered GABA on hippocampus was investigated by recording its electrical activity after chronic implantation of cannulae and bipolar electrode in five male beagle dogs. GABA was introduced in 40 mg/Kg b. weight so as to exceed its physiological levels in CSF. Recordings were made within two hours after microinjection in third ventricle. The predominant pattern of EEG depicted synchronization. The progressing synchronization of EEG suggests induction of functional lesion which might be playing a protective role in the regulation of metabolic behaviour.
Subject(s)
Animals , Dogs , Electroencephalography/drug effects , Evoked Potentials/drug effects , Hippocampus/drug effects , Injections, Intraventricular , Male , gamma-Aminobutyric Acid/drug effectsABSTRACT
Effect of intracerebroventricular (i.c.v.) ethanol on pre-optic area (POA) and hippocampus (HPC) was investigated by recording chronological changes in their electroencephalographic (EEG) activity, through chronically implanted cannulae and bipolar electrodes, in five conscious male beagle dogs. Recordings were made for two hours after microinjection and compared with cortical (CO) tracings. The predominant pattern of EEG activity from subcortical loci was high voltage discharges though synchronization was also observed. Cortical EEG depicted slow waves with some potentiation. The study demonstrated similar type of response form POA and HPC, which was different from CO, suggesting that ethanol produces different actions at subcortical and cortical level.