ABSTRACT
Chronic coronary syndromes are usually considered uncommon in young women, related to slower progression of atherosclerotic coronary artery disease, have atypical clinical presentations, and experience less diagnostic investigation. Non-atherosclerotic causes of coronary artery disease should be considered in young women experiencing angina. We report a 25-year-old woman who consulted for five months of moderate exertion angina. Physical examination revealed a right carotid bruit and asymmetrical upper extremity peripheral pulses. Initial work-up and imaging allowed to diagnose aortitis with bilateral coronary ostial stenosis secondary to Takayasu's arteritis. The patient experienced an apparent clinical response to initial medical therapy. However, follow-up evaluation revealed persistence of significant ischemia and requirement for myocardial revascularization. A percutaneous coronary intervention was performed.
Los síndromes coronaries crónicos son infrecuentes en mujeres jóvenes, quienes suelen presentar una lenta progresión de enfermedad coronaria aterosclerótica, tienen presentación clínica atípica y son menos sujetas a exploración diagnostica. Se deben considerar causas no ateroscleróticas de enfermedad coronaria en mujeres jóvenes con angina. Informamos una paciente de 25 años que consultó por cinco meses de angina con esfuerzos moderados. Al examen físico presentaba un soplo carotideo derecho y pulsos asimétricos de extremidades superiores. La exploración de laboratorio inicial y posterior evaluación multimodal permitió evidenciar la presencia de aortitis y estenosis de ambos ostium coronarios, concordante con el diagnóstico de una arteritis de Takayasu. Inició terapia medica con respuesta clínica aparentemente favorable. No obstante, la evaluación cardiológica no invasiva en el seguimiento permitió corroborar la persistencia de isquemia significativa y necesidad de revascularización miocárdica. Se realizó una intervención coronaria percutánea de ambos ostium, con una evolución favorable.
Subject(s)
Humans , Female , Adult , Coronary Artery Disease , Takayasu Arteritis/complications , Takayasu Arteritis/diagnostic imaging , ArteriesABSTRACT
ABSTRACT: Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies.
RESUMO: O câncer ainda é uma das principais causas de morte no mundo. Muitos quimioterápicos de plantas foram testados em câncer, como vinblastina e paclitaxel. O norte do Chile, região de Arica e Parinacota, caracteriza-se por sua biodiversidade vegetal devido às suas condições geográficas e climatológicas únicas, oferecendo uma fonte inexplorada e única de compostos de origem natural. A presente pesquisa considerou uma triagem de 26 ervas das terras altas usando um modelo de inibição de crescimento in vitro em um painel de seis linhas celulares de câncer de diferentes tecidos. Cinco, dos 26 extratos etanólicos estudados, mostram forte atividade pelo menos em uma linhagem celular quando testados a 10 µg mL-1. Apresentamos um grupo de plantas dignas de serem avaliadas como extratos promissórios. Este trabalho faz parte da tentativa sistemática de encontrar novos candidatos para serem usados em terapias contra o câncer.
Subject(s)
Humans , Child , Cell Phone , Freedom , Cyberbullying/prevention & control , Schools , Chile , Social Media , Cyberbullying/psychologyABSTRACT
ABSTRACT: Baccharis alnifolia Meyen & Walp. is a native and medicinal, Chilean Altiplano herb that is used as a poultice and also consumed as an infusion to relieve inflammation. This study evaluated the antioxidant and cytotoxic effect of the ethanolic extract of B. alnifolia and their infusion. It was reported that the ethanol extract contains 4.42 mg GAE/g of dry weight and the infusion contains 35.86 mg GAE/L of total polyphenols. Also, it determined the antioxidant capacity using Ferric reducing antioxidant power (FRAP), Oxygen Radical Absorbance Capacity (ORAC) and Trolox equivalent antioxidant capacity (TEAC) assay. Moreover, seven metabolites including between phenolic acids and flavonoids were identified for the first time in both extracts of the medicinal plant Baccharis alnifolia. The UHPLC-DAD chromatograms revealed the majority presence of ferulic acid and luteolin, both could be responsible for the antioxidant and cytotoxic activity. Furthermore, we realized a preliminary screening of cytotoxicity in different tumor cell lines, finding that these extracts have cytotoxic potential on kidney cells.
RESUMO: Baccharis alnifolia Meyen & Walp. é uma erva altiplana nativa e medicinal, chilena que é usada como cataplasma e também consumida como uma infusão para aliviar a inflamação. Este estudo avaliou o efeito antioxidante e citotóxico do extrato etanólico de B. alnifolia e sua infusão. Verificou-se que o extrato etanólico contém 4,42 mg GAE / g de peso seco e a infusão contém 35,86 mg GAE / L de polifenóis totais. Além disso, determinou a capacidade antioxidante utilizando o poder antioxidante redutor de Fração (FRAP), Capacidade de Absorção Radical de Oxigênio (ORAC) e capacidade antioxidante equivalente de Trolox (TEAC). Além disso, sete metabólitos, entre ácidos fenólicos e flavonóides, foram identificados pela primeira vez em ambos os extratos da planta medicinal Baccharis alnifolia. Os cromatogramas UHPLC-DAD revelaram a presença majoritária de ácido ferúlico e luteolina, ambos podendo ser responsáveis pela atividade antioxidante e citotóxica. Além disso, realizamos uma triagem preliminar da citotoxicidade em diferentes linhagens de células tumorais, descobrindo que esses extratos têm potencial citotóxico nas células renais.
ABSTRACT
Carcinoid syndrome is observed in one third of carcinoid tumors and usually appears when there are liver metastases. One of the main complications of this syndrome is the appearance of tricuspid or pulmonary valvular disease. We report a 56 years old male presenting with malaise and a weight loss of 10 kg. On physical examination, a heart murmur suspicious of a double tricuspid lesion was found. The echocardiogram was suggestive of a carcinoid valvular disease. The abdominal CAT scan showed a small bowel tumor. Urinary 5-hydroxy-indol- acetic acid values were highly elevated. The patient was subjected to excision of the distal ileum, liver metastasectomy and hemicolectomy. The pathological study of the surgical piece confirmed the diagnosis of carcinoid tumor. Two years after surgery, the patient is in stable conditions.
Subject(s)
Humans , Male , Middle Aged , Carcinoid Heart Disease/diagnosis , Malignant Carcinoid Syndrome/diagnosis , Organometallic Compounds , Hydroxyindoleacetic Acid , Liver Neoplasms/secondary , Intestinal Neoplasms/secondary , Positron-Emission Tomography , Malignant Carcinoid Syndrome/pathology , Tomography, X-Ray ComputedABSTRACT
En este artículo se exponen aspectos centrales de la cosmovisión mapuche relacionados con la enfermedad y la sanación. Se abordan los conceptos de equilibrio, desequilibrio, energía negativa y energía positiva, indicando las palabras empleadas en el mapudungun o idioma nativo mapuche. Se describen actividades de los agentes de la sanación mapuche, rol de estas personas y sus acciones frente a la enfermedad. Se presenta la función de la persona que tiene rol de machi. Se aborda el impacto de la cultura occidental sobre las costumbres, la cultura pehuenche, el sistema curativo y la salud de los mapuches.
Subject(s)
Humans , Community Health Workers , Disease/ethnology , Health , Indians, South American , Medicine, Traditional , Health Services, Indigenous , Anthropology, Cultural , Chile , EthnicitySubject(s)
Humans , Female , Aged , Echocardiography, Transesophageal , Pulmonary Embolism , Arthroplasty, Replacement, Hip , Dyspnea , Femoral Vein , Heparin , Leg , Pulmonary EmbolismSubject(s)
Adult , Middle Aged , Humans , Male , Female , Atrial Fibrillation/drug therapy , Atrial Flutter/drug therapy , Propafenone/therapeutic use , Tachycardia, Supraventricular/drug therapy , Aged, 80 and over , Prospective Studies , Electrocardiography , Heart Rate/drug effects , Arterial PressureABSTRACT
Se evaluaron los efectos clínicos y electrocardiográficos de 2mg/kg de acetato de flecainida administrados por vía intravenosa en 27 pacientes: portadores de TPSV (11p), FA(8) y F(8). De los 11 p con TPSV, 9 convirtieron a RS precozmente. De los 8 p con FA, uno convirtió a RS y de los 8 p con F, uno revertió a RS. La frecuencia ventricular de la FA que no convirtió a RS, disminuyó en forma significativa. La frecuencia auricular del fluter se redujo en forma importante de (273) ñ 33 a (202) ñ 7 ciclos/min. (p <0.001). En dos enfermos hubo un efecto que catalogamos de pro-arrítmico: una taquicardia ventricular sostenida y un flutter auricular con conducción A/V 1:1 (7,4%). La duración del QRS aumentó de 87 ñ 18 ms a 108 ñ 24 ms (p <0.001). No hubo cambios significativos de la presión arterial ni síntomas adversos durante la administración del fármaco