ABSTRACT
Background: Antiretroviral treatment (ART) has substantially reduced morbidity and mortality for HIV patients. In South Africa; with the largest ART programme globally; attention is needed not only on the further expansion of ART coverage; but also on factors which undermine its effectiveness; such as alcohol use. Objective: South African primary health sector; it is important to document key aspects of alcohol use to be conveyed to HIV-positive individuals and those at risk for HIV. Method: This study comprised a narrative review of relevant literature. Results: Alcohol acts through both behavioural and physiological pathways to impact on the acquisition; further transmission and then progression of HIV disease. Besides links to risky sex; alcohol undermines the immune system; raising susceptibility to contracting and then countering HIV and other infections. There are important drug interactions between alcohol and ART; or therapies for opportunistic infections and other co-morbidities. Moreover; alcohol undermines adherence to the medication which is essential for effective ART. Conclusion: Primary healthcare clinic attendees need evidence-based information on the detrimental effects of alcohol consumption on HIV infection; which ensue throughout the clinical course of HIV. This spans the role of alcohol consumption as a risk factor for HIV infection; HIV replication in infected individuals; a person's response to HIV infection and HIV treatment. Primary healthcare workers; especially nurses and HIV counsellors; require training in order to screen for and provide appropriate interventions for HIV-positive patients; those on treatment and treatment-naive patients; who will benefit from reduced alcohol consumption or the cessation thereof