ABSTRACT
Objective: To assess height velocity and develop height velocitypercentiles in 5-17-year-old Indian children; and to study themagnitude and age at peak height velocity.Design: Mixed longitudinal study.Setting: Private schools at Pune and Delhi.Participants/patients: 2949 children (1681 boys) belonging toaffluent class aged 5-17 years (1473-Pune, 1476-Delhi).Methods: Annual height and weight measurements from 2007 to2013. Total 13214 height velocity measurements (7724 on boys).Outcome Measures: Height velocity percentiles (3rd, 10th, 25th,50th, 75th, 90th and 97th) constructed using LMS chart maker.Results: Age- and gender-specific height velocity percentileswere generated. Median height velocity in girls decreased from 5to 8 years, increased to a peak of 6.6 cm at 10.5 years and thendeclined to 0.3 cm at 17.5 years. In boys, median height velocityreduced till 10.5, increased to a peak of 6.8 cms at 13.5 years andthen declined to 1cm by 18 years.Conclusions: Height velocity percentiles in 5-17-year-old urbanIndian children were constructed
ABSTRACT
Objective: To study longitudinal growth in children with type 1 diabetes mellitus. Methods: Anthropometry, disease duration, insulin regimens and HbA1C recorded from patients with diabetes enrolled in a specialty clinic. Results: 160 children (75 boys; mean (SD) age 9.4 (3.3) y) were enrolled. 35% children had low (<25th centile) height velocity. Disease duration and HbA1 C affected height velocity (adjusted for puberty). Children on basal-bolus had higher height velocity Z scores than those on a split mix regimen [(0.5(1.6) vs. -0.3(1.4), P<0.05)]. Children diagnosed before 5 years of age had lowest height velocity. Of the children who reached final height, 53% remained below target height. Conclusion: Children with type 1 diabetes mellitus have lower height velocity compared to healthy children; those diagnosed at younger age were at higher risk for growth failure.
ABSTRACT
Objectives: To compare lipid parameters between diabetics and controls and to study association between metabolic control and lipid profile. Methods: Lipid profile and HbA1c were measured (n=80, 39 boys) in diabetic children [age 10.7(3.4) y] and 54 controls, tests repeated after 1 year (in 45 diabetics). Results: Diabetic children had higher mean (SD) LDL-C [95.3(27.7) vs 84.5(26.4) mg/dL], lower HDL-C [48.2 (13.1) vs 53.1(11.9) mg/dl]. Moderate physical activity (P=0.014) protected against high LDL-C levels. HbA1c (P=0.00) predicted total and LDL-C levels. At 1year, 63% showed reduced LDL-C with improving HbA1c; 72% showed increased LDL-C with deteriorated HbA1c. Conclusion: Improving metabolic control is cardinal to reduce cardiometabolic risk; physical activity is beneficial.