ABSTRACT
Traditional treatments and medicines are the main sometimes the only source of health care for millions of people living in rural areas of developing countries. The aim of the present study is to investigate the analgesic and antipyretic activity of individual plant extracts and poly-herbal formula [PHF] made in to liquid dosage form of three different doses in albino rats. The plant materials were extracted in boiling distilled water for six hours, filtered, concentrated and dried. The aqueous extracts were prepared in to poly-herbal liquid dosage form by using water, glycerol mixture and acacia 2% in three different preparation of varying extract doses.1ml of above preparations orally fed for investigation. Pentozocine and paracetamol was used as standard drugs respectively. For individual plants the extracts were suspended in 2% acacia solution and performed. The results of analgesic and anti-pyretic activity of PHF 1 and PHF 2 showed significant results (P<0.01 and P<0.05 respectively) and PHF3 did not show any significant results. In the individual plant extracts slightly significant activity (P<0.05) was observed.
ABSTRACT
Fioria vitifolia Linn., (Malvacae) has been extensively used in folk medicine for the treatment of common cold, flu, and upper respiratory infections and also as an immune system booster. Steroids, flavonoids, and triterpenes, gossypin alkaloids have been isolated from the whole part of the plant. In the present study, the methanolic extract of dried plant of Fioria vitifolia (MEFV) was investigated for anti-inflammatory (carrageenan induced rat paw oedema) and anti-pyretic (brewer’s yeast induced pyrexia) activities. Pre-treatment with the extract (250-500mg/ kg, p. o) significantly prevented increase in volume of paw oedema in dose dependent manner. A maximal effect was observed at 500mg/kg which was comparable to diclofenac (20mg/kg, orally). Ceiling effect at the dose of 500mg/kg was observed. The anti-pyretic effect of MEFV (measured as % reduction in body temperature) was compared with paracetamol (150mg/kg, orally). MEFV in dose of 500mg/kg caused significant decrease in body temperature of rats. In conclusion, this study has established the anti-inflammatory activity and anti pyretic activity of Fioria vitifolia and thus, justifies the ethnicuses of the plant.
ABSTRACT
Traditional treatments and medicines are the main sometimes the only source of health care for millions of people living in rural areas of developing countries. The aim of the present study is to investigate the analgesic and antipyretic activity of individual plant extracts and poly-herbal formula [PHF] made in to liquid dosage form of three different doses in albino rats. The plant materials were extracted in boiling distilled water for six hours, filtered, concentrated and dried. The aqueous extracts were prepared in to poly-herbal liquid dosage form by using water, glycerol mixture and acacia 2% in three different preparation of varying extract doses.1ml of above preparations orally fed for investigation. Pentozocine and paracetamol was used as standard drugs respectively. For individual plants the extracts were suspended in 2% acacia solution and performed. The results of analgesic and anti-pyretic activity of PHF 1 and PHF 2 showed significant results (P<0.01 and P<0.05 respectively) and PHF3 did not show any significant results. In the individual plant extracts slightly significant activity (P<0.05) was observed.
ABSTRACT
Fioria vitifolia Linn., (Malvacae) has been extensively used in folk medicine for the treatment of common cold, flu, and upper respiratory infections and also as an immune system booster. Steroids, flavonoids, and triterpenes, gossypin alkaloids have been isolated from the whole part of the plant. In the present study, the methanolic extract of dried plant of Fioria vitifolia (MEFV) was investigated for anti-inflammatory (carrageenan induced rat paw oedema) and anti-pyretic (brewer’s yeast induced pyrexia) activities. Pre-treatment with the extract (250-500mg/ kg, p. o) significantly prevented increase in volume of paw oedema in dose dependent manner. A maximal effect was observed at 500mg/kg which was comparable to diclofenac (20mg/kg, orally). Ceiling effect at the dose of 500mg/kg was observed. The anti-pyretic effect of MEFV (measured as % reduction in body temperature) was compared with paracetamol (150mg/kg, orally). MEFV in dose of 500mg/kg caused significant decrease in body temperature of rats. In conclusion, this study has established the anti-inflammatory activity and anti pyretic activity of Fioria vitifolia and thus, justifies the ethnicuses of the plant.