ABSTRACT
Cassia senna leaves belonging to the family Fabaceae have been investigated for the presence of its secondary metabolites and evaluation of biological activities of the crude extracts with special emphasis to the antimicrobial activity, cytotoxic activity and thrombolytic activity. The antimicrobial activities of n-hexane, chloroform, ethyl acetate & methanolic extracts of C. senna leaves were screened against five gram(+) bacteria, eight gram(-) bacteria and three fungi by ‘disc diffusion method’. The methanol extract possesses no antimicrobial activity but chloroform and n-hexane fractions exhibited moderate to less activity against some organisms tested compared with the standard antibiotic Kanamycin. Brine shrimp lethality bio-assay was done using brine shrimp Nauplii and dimethyl sulfoxide as a solvent for the methanol extracts of C. senna. The LC50 value (1.5625) of methanol extract of the plant indicated that the cytotoxicity was very significant. The percentages found in thrombolytic tests are 41.46%, 53.22%, 33.33%, 4.08% and standard 92.85%. So, in comparison with standard, C. senna can be further use as mild thrombolytic agent.
ABSTRACT
The aim of this study was to evaluate the anti-oxidant and anti-choline esterase activity of the stem, barks and leaves of the plant V. cinerea. The stems, barks and the leaves of the plant V.Cineria was sun dried and extracted using methanol. The anti-oxidant activity of the crude methanolic extract was measured by the DPPH free radical scavenging activity. The crude methanolic extract showed significant anti-oxidant activity by the DPPH free radical scavenging method. Evaluation of ChEs enzyme activity of the crude methanolic extract was done by Ellman method. The methanolic extract of V. cinerea leaves exerted significant AChE and BChE inhibitory effects.
ABSTRACT
Gout is a common metabolic disorder which occurs due to excessive deposition of uric acid in different bone joints. Increasing life expectancy, life style change, changes in diet are causing an increased incidence of the disease nowadays. The present study was aimed to understand the pattern and treatment of gout in Bangladesh. 150 patients at four tertiary care hospitals in Dhaka city were surveyed. The findings of the present study suggests that both male and female are suffering from the disease and age seems to be related to the disease as 62% of gout patients were found over 50 years of age. Body weight may be a contributing factor of the disease. Most of the gout patients under the survey were suffering from high blood pressure (65.33%). Primary gout was found more prevalent in this investigation (70.66%) and viral hepatitis was found to be the most common cause of the disease (50%). The patients presented common sign and symptoms of gout.
ABSTRACT
Hepatitis is common disease in Bangladesh. As a country of the Asia Pacific region Bangladesh is considered to be a high risk country for developing hepatitis A and B. This study represents the pattern and types of treatment of hepatitis in two tertiary care hospitals in Bangladesh; Bangabandhu Sheikh Mujib Medical University and Dhaka Medical Collage Hospital. 140 patients were selected among whom 80 were male and 60 female. The patients were asked to fill up a questioner. Prescriptions of all the patients were reviewed and the duty doctors were consulted for further clarification of the cases. From the data obtained over a 3 month long survey it was found that hepatitis A, B and C are most common in this country. Most of the patients develop classical sign and symptoms of hepatitis; most commonly jaundice and weight loss. About 50% hepatitis cases contributed a viral cause. 42.86% patients undergo preventive treatment whereas 57.14% patients are treated with drugs. Lamivudine, Adefovir and Ribavirin were the commonly used drugs in viral hepatitis. The prevalence of different forms of hepatitis in Bangladesh is high. Bangladesh is at the high risk region of hepatitis A and B. Routine immunizations and community education regarding the diseases are highly warranted here