ABSTRACT
Context: There are very few studies concerning the role of denture status in temporomandibular disorders (TMDs) and those show conflicting results. Aim: To evaluate the association of edentulousness and removable prosthesis rehabilitation with severity of TMD signs and symptoms. Settings and Design: Data were collected from 2000 subjects reporting for dental treatment, above 30 years of age. Subjects and Methods: The subjects were interviewed with a questionnaire and clinically examined for TMD on basis of Helkimo’s index. The number of existing teeth, wearing of removable dentures, need for denture repair, and age of dentures was recorded. Statistical Analysis: The association between the TMD findings and recorded variable outcomes was analyzed by means of Chi‑square test. Results: Completely edentulous individuals associated more with TMD related findings in incidence and intensity than partially/fully dentate subjects. Complete denture wearers were more associated with TMD symptoms, limited mandibular mobility, muscle tenderness, and pain on mandibular movement. Partial denture wearers were more associated with severely impaired temporomandibular joint function and joint pain. Signs and symptoms of TMD were more prevalent and severe in patients who needed to get their dentures repaired, those wearing dentures more than 5‑year‑old, and in patients who had not got their dentures repaired during the past 5 years. Conclusions: Edentulousness, complete/partial denture wearing and poor condition of the dentures associate with greater incidence and intensity of TMD associated signs and symptoms.
ABSTRACT
Aim of the study was to investigate Gastroprotective and anti-secretory effect of Pep-Up Tablet on pyloric ligation-induced gastric ulcer model in rats. Pep-Up Tablet is an Ayurvedic proprietary formulation which is manufactured and marketed by Vasu Healthcare Pvt. Ltd., Vadodara. The selected animals were divided into two groups and each group consisted of six animals. Group-I was considered as disease control and Group-II was as test drug (Pep-Up Tablet) treated group. Pep-Up Tablet (200 mg/kg/day, p.o.) was administered for 7 days by oral route in Group-II. Pep-Up Tablet was studied for its effect on ulcer index, gastric wall secretory parameters and mucin activity. Pretreatment of Pep-Up Tablet showed significant reduction in ulcer index, gastric acid secretion and pepsin activity. Pep-Up Tablet significantly increased mucin activity (TC:TP ratio) as well which was due to significant increase in the total carbohydrate content. From the available data of present study, it can be concluded that Pep-Up Tablet plays important role mainly on inhibition of acid secretion and in increase of mucin secretion which in turn enhances the stability of gastric mucosal barrier. Pep-Up Tablet provided significant gastric cytoprotection against pyloric ligation-induced gastric ulceration in rats.
ABSTRACT
Background: Glucova Active Tablet is a proprietary Ayurvedic formulation with ingredients reported for anti-hyperglycemic, anti-hyperlipidemic activity and antioxidant properties. Objective: Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats. Materials and Methods: Experimental Type I diabetes was induced in 24 albino rats with intra-peritoneal injection of streptozotocin (50 mg/kg). Type II diabetes was induced in 18 albino rats by intra-peritoneal injection of streptozotocin (35 mg/kg) al ong with high fat diet. The rats were divided in 5 groups for Type I model and 4 groups for Type II model. Normal control group was kept common for both experimental models. Glucova Active Tablet (108 mg/kg) treatment was provided for 28 days twice daily orally. Fasting blood glucose level, serum lipid profi le and liver anti-oxidant parameters like superoxide dismutase and reduced glutathione was carried out in both experimental models. Pancreas histopathology was also done. Statistical analysis were done by 'analysis of variance' test followed by post hoc Tukey’s test, with signifi cant level of P < 0.05. Results and Discussion: Glucova Active Tablet showed signifi cant effect on fasting blood glucose level. It also showed signifi cant alteration in lipid profi le and antioxidant parameters. Histopathology study revealed restoration of beta cells in pancreas in Glucova Active Tablet treated group. Conclusion: Finding of this study concludes that Glucova Active Tablet has shown promising anti-diabetic activity in Type I and Type II diabetic rats. It was also found showing good anti-hyperlipidemic activity and anti-oxidant property.