ABSTRACT
Background: PIH, a pregnancy-specific disorder, is one of the major causes of maternal and perinatal morbidity and mortality worldwide.PIH and fetal growth restriction are important causes of perinatal and maternal morbidity and mortility.Methods: Hundred Indian pregnant women in their second trimester (13-20 weeks) and in their late second trimester (24-28 weeks) investigated for their serum β-hCG level and uterine artery Doppler studies respectively, attending OPD/IPD in Sir T. hospital, Bhavnagar from June 2014 to June 2015.Results: There is no clinical significance between parity and occurrence of PIH (p=0.2) and FGR (p=0.7). Out of 77 patients with their β hCG level ≤2 MoM, 2 patients (2.59%) developed PIH and FGR. And from 12 patients with their β hCG level ≥2 MoM 10 patients (80%) developed PIH and FGR which is highly significant (p<0.001). The study establishes the validity of beta HCG as a predictor of PIH and FGR with the sensitivity of 83.3%, specificity of 97.5%.Conclusions: This study can be concluded by there is a strong association between high maternal serum ß-hCG level, abnormal uterine Doppler studies with predicting adverse outcome of pregnancy like PIH and FGR. There is also a good association between high maternal serum ß-hCG level and rising severity of the disease.
ABSTRACT
Background: The aim of the study was to know occurrence, incidence, and various histopathological variants of eyelid tumors.It is incidence with respect to age and to analyse the distribution of tumors in various age group at new civil Hospital, Asarwa,Ahmedabad.Materials and Methods: A total of 100 cases of eyelid tumors were analyzed retrospectively in a period from May 2008to November 2010. Cases were studied in detail about general information of the patient including age and sex and grossexamination and histological features.Result: Of 100 tumors, 56 (56%) were benign and 44 (44%) were malignant. Of 56 benign lesions, 41 were in pediatric agegroup (<18 years) and 15 were in adult patients (>18 years). The common benign lesion seen was nevi (21%) followed bysquamous papilloma (12%). The common malignant lesion seen was meibomian gland carcinoma (22%) followed by basal cellcarcinoma (12%). Distribution of tumor based on origin on descending order was epithelial origin (33%), adnexal origin (23%),melanocytic origin (22%), and mesenchymal origin (22%).Conclusion: As eyelid skin is the thinnest and most sensitive skin in our body, it is often the first area in body to show changesoccur from sun damage and aging. Skin cancer of the eyelids is relatively common and of several types. Overall, the incidenceof benign tumors (56%) was more than malignant tumors (44%) in the present study. Benign tumors were more common inadolescent and young adults. Mean age of benign tumors was 33.83 years. Malignant tumors were more common in elderly. Meanage of malignant tumors was 61.40 years. Overall, sex distribution of benign and malignant tumors is equal in both the sexes.
ABSTRACT
Background: Malaria is the most important disease of human being. More than 40% of the world’s population is considered to be at risk of exposure of this disease. Malaria infection has been increasing over recent years due to combination of factors including increasing resistance of malarial parasite. Most of the strains of P. falciparum are now resistance to conventional drugs like chloroquine in many areas. The objective of this study was to compare the efficacy and safety of quinine and artesunate in treatment of P. falciparum malaria. Methods: This is hospital based prospective study, conducted amongst 35 randomly selected patients of severe P. falciparum malaria. Patients with any contraindications of either drug were excluded to avoid bias. Standard statistical tests were applied for qualitative as well as quantitative data. Results: As per the study end point results of difference of mortality in patients receiving either drug was not significant (p > 0.75), but difference in clinical parameters like fever clearance time (p <0.01), parasite clearance time (p < 0.001) and coma resolution time (p < 0.001) were significant among patients receiving artesunate. There were no any significant differences in adverse effects of both the drugs. Mortality was same in both arms taking either drug. Conclusions: Artesunate is as good as quinine in mortality aspect but artesunate is superior in fever clearance time (FCT) & parasite clearance time (PCT). Coma resolution time is faster with quinine as compared to artesunate. There are no significant adverse effects of either drug. So artesunate is equivalent or superior for treatment for severe falciparum malaria. Key words: Severe falciparum malaria, Quinine
ABSTRACT
Wilson disease of Progressive Lenticular Degeneration is a familial nervous disease associated with Cirrhosis of the Liver. It has been observed that there is an increased copper content of the liver and brain. Increased excretion of copper in patients with Wilson disease & increased even more after administration of the chelating agent British anti-Lewisite (BAL). Ciruloplasmin, serum protein that binds copper, is reduced. The deposition of copper in tissues is the cause of virtually all the manifestations of the disease in Liver Blood Kidney & Brain We have observed three different cases of different clinical presentations.