ABSTRACT
Background: Advances in oral and periodontal disease diagnostic research are moving towards methods wherein periodontal risk can be identified and quantified by objective measures such as bio?markers. Given the roles of vitamin D binding protein (DBP) in modulating the immune response and in the transport of vitamin D, it is hypothesised that quantitative changes of vitamin DBP are associated with periodontal disease. Aim: The aim of the current study is to measure DBP levels in serum and gingival crevicular fluid (GCF) of patients with generalised chronic periodontitis, in comparison to healthy controls. Materials and Methods: The present cross?sectional clinico?bio?chemical study includes 30 systemically healthy subjects with 15 periodontally healthy and 15 chronic periodontitis subjects who were recruited from the out?patient Department of Periodontics. GCF and blood samples were collected from all the patients. DBP estimation was performed in both the samples using a commercially available ELISA kit. Results: Serum and GCF DBP levels in chronic periodontitis subjects were significantly higher when compared to the periodontally healthy group. There were no significant correlations found among serum and GCF DBP levels with gender and increasing age in both the groups. An increase in disease severity measured by the increase in probing pocket depth and clinical attachment loss did not show correlation with the GCF and serum DBP levels in the chronic periodontitis group. Conclusion: Based on the findings of the present study, increased serum and GCF DBP levels in chronic periodontitis seem to be a probable marker for identifying ongoing periodontal destruction.
ABSTRACT
Background: The localized inflammatory reaction to periodontal pathogenic bacteria or bacterial products is characterized by penetration of the periodontal tissues by inflammatory cells. Recent studies demonstrate the relation between periodontal disease (PD) and hyperlipidemia, which influence the likelihood of PD as an underlying factor for hyperlipidemia. Aim: The aim of this Randomized, case-control type of study was to elucidate the association between serum lipid parameters in periodontally diseased patients with healthy individuals. Material and methods: A total number of 44 subjects were segregated into two groups Group A (Control) Group B (Test). Periodontal parameters including Oral hygiene Index-Simplified (OHI-S), Gingival Index (GI), Probing Depth (PD) and Clinical Attachment Level (CAL) were recorded. Lipid profile comprising of Serum cholesterol, Triglycerides, HDL- Cholesterol and LDL was assessed and co related with periodontal parameters. Vani Chappidi, Pradeep Koppolu, Lingam Amara Swapna, Sridhar Reddy Erugula, Krishnajaneya Reddy Pathakota. Effect of Chronic Periodontitis on Serum Lipid Profile: A Randomized, Case Control Clinico-biochemical Study. IAIM, 2017; 4(10): 67-71. Page 68 Results: The results of the present study demonstrated a positive correlation between GI, PD, OHI-S and CAL with serum cholesterol, TG and LDL. The Serum cholesterol, Triglycerides and LDL levels between both the groups showed statistical significance. But the serum HDL levels when compared between both the groups were not statistically significant. Conclusion: The present study showed a definitive positive correlation between PD and increased lipid levels.