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Indian J Physiol Pharmacol ; 1994 Jul; 38(3): 169-73
Article in English | IMSEAR | ID: sea-107366

ABSTRACT

The present investigation was undertaken to study the interaction of fluoxetine with 5-hydroxytryptamine (5-HT) and noradrenaline (NA) in rat anococcygeus muscle and vas-deferens. In rat anococcygeus muscle responses to NA were significantly potentiated after 30 min and 60 min incubation with fluoxetine (2.9 x 10(-9) M). The responses to 5-HT were however, inhibited after 30 min incubation with fluoxetine in this preparation. On rat vas-deferens also, the responses to NA were potentiated after 30 min incubation with fluoxetine. The response to 5-HT were not altered significantly. In rats pretreated with fluoxetine (5 mg/kg, ip) for seven days, the responses to NA were significantly potentiated in rat anococcygeus muscle. Whereas the responses to 5-HT and tyramine were significantly inhibited. The inhibited responses to 5-HT restored back to normal when the anococcygeus muscle was pre-incubated with NA for 30 min.


Subject(s)
Animals , Dose-Response Relationship, Drug , Drug Interactions , Fluoxetine/pharmacology , Male , Muscle Contraction/drug effects , Muscle, Skeletal/drug effects , Muscle, Smooth/drug effects , Norepinephrine/antagonists & inhibitors , Rats , Rats, Wistar , Serotonin/pharmacology , Serotonin Antagonists/pharmacology , Tyramine/pharmacology , Vas Deferens/drug effects
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