ABSTRACT
Background: The I-gel is a latex-free SAD that has a non-inflatable cuff and medical-grade thermoplastic elastomer. The design allows for a more close interaction when engaging with supraglottic tissue. The goal of the present prospective study was to compare the performance of the I-gel with that of the LMA-Supreme. Methods: The present prospective study was conducted on 100 adult patients with age between 18 to 60 years with American Society of Anesthesiologists (ASA) physical status I or II who were scheduled to undergo elective laparoscopic Gynecological procedure under general anesthesia were included in the study. Patient having gastric reflux, Obesity (BMI >30kg/m2), cervical spine disease or difficult airway were excluded from the study. The study was conducted after obtaining approval from the Institutional Review Board. A written informed consent for participation in the study was obtained from each patient. Results: The mean time for insertion in the Group SLMA was 29 sec which was significantly more as compared to 21 sec in Group I-gel (p<0.0001). 84% cases from the Group I-gel had ease of insertion which was significantly more as compared to 82% among the Group SLMA. There was no significant difference in the incidence of postoperative complications between the groups (p>0.05). Conclusion: In conclusion, both devices were similarly successful ventilatory devices for gynaecological laparoscopic procedures in terms of ease of insertion, first-time success rates, time to insertion, and oropharyngeal leak pressure
ABSTRACT
The objective of present study was to investigate Petroleum ether, ethyl acetate and hydroalcoholic extracts of B. racemosa fruits in vitro on human polymorphonuclear (PMN) cells to screen their effects on phagocytosis and chemotaxis. Ethyl acetate extract of B. racemosa fruitswas found to be a stimulant of PMN cell phagocytosis of Nitroblue tetrazolium (NBT) dye and candida albicans. It also stimulated intracellur killing capacity of PMN cells. It was further found to increase the chemotaxis of human PMN cells.While, petroleum ether extract and hydroalcoholic extract were lesser active as far as these activities are concerned.
ABSTRACT
Background: Barringtonia racemosa (B. racemosa) is used medicinally in treatment of diarrhoea, asthma, coughs, jaundice. It is also used as an analgesic and antipyretic. This plant has also significant anti-tumor activity. However, systematic evaluation of its immunomodulatory effects has not been reported. In present study the hydroalcoholic extract of fruits of B. racemosa has been evaluated for its immunomodulatory properties in animal models. Methods: Extract of Fruits of B. racemosa was prepared from fruit powder and methanol by macerations and filtration. Healthy albino Wistar rats of either sex having 110-160 g body weight were used for this study. 1. Delayed type hypersensitivity reaction (DTH) using Sheep red blood cells (SRBCs): After immunization with SRBC effect of cyclophosphamide and hydroalcoholic extract of B. racemosa was seen on paw volume changes in rats challenged with SRBC by using digital Plethysmometer. 2. Humoral antibody response to SRBC: Animas were immunized with SRBC and treated with cyclophosphamide and hydroalcoholic extract of B. racemosa. Serum of these animals was observed for haemagglutination titer. Results: Fruits extract at the dose of 5 mg/kg i.p. showed significant decrease in DTH response as compared to that of control group animals. However, the effect of extract was less potent as compared to that of cyclophosphamide treated group. In haemagglutination titer assay, antibody titer in case naïve control, SRBC treated, cyclophosphamide treated and extract treated groups was 1:1, 1:32, 1:8 and 1:16 respectively. Conclusions: The hydroalcoholic extract of this fruits was found to inhibit SRBCs induced DTH in rats. Similarly, SRBCs induced antibody titer was also reduced.