Evaluation of Efficacy and Safety of Evecare Syrup in Menstrual Irregularities: A Multicentric, Post Marketing Surveillance Study.

A total of 1,000 female patients aged between 18-45 years with menstrual irregularities and those willing to give informed consent were included in this multicentric, post marketing surveillance study. At the initial visit, a detailed medical history, symptomatic evaluation and gynecological evaluation was carried out in all the patients. Out of the 1,000 patients, 372 had dysmenorrhea, 388 had menorrhagia and 240 patients had oligomenorrhea. Each patient was administered Evecare Syrup at a dose of 15 ml, twice-daily for a period of three months. Statistical analysis was carried out using GraphPad Prism, Version 4.03. In 372 patients suffering from dysmenorrhea, 14 had slight abdominal pain and 358 of them had total absence of symptoms at the end of treatment. In patients with menorrhagia, significant reduction was observed in the mean score of duration of menstruation, quantity of blood loss, blood flow loss and character of blood flow changed from clot to flow after treatment with Evecare Syrup. At the end of three months of treatment, 238 patients had normal menstruation, normal duration and flow in oligomenorrhea. No clinically significant adverse drug reactions were reported except for one patient, who had symptoms of nausea; one patient had symptoms of gaseous distension at third month of treatment and it did not require additional treatment or drug withdrawal. The results of the present study showing clinical benefit of Evecare Syrup appear promising in the management of menstrual irregularities.

Double-blind, placebo-controlled clinical evaluation of an Ayurvedic formulation (GlucoCare capsules) in non-insulin dependent diabetes mellitus.

Diabetes mellitus describes a metabolic disorder of multiple etiologies characterized by insulin resistance, relative insulin deficiency and hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. The goal for treatment of diabetes is to prevent its acute manifestations and long-term microvascular and macrovascular complications. The present study was conducted to evaluate the efficacy and safety of an Ayurvedic formulation (GlucoCare Capsules) in non-insulin dependent diabetes mellitus. Fifty NIDDM patients of pitta-kapha prakriti attending the outpatient department of the Government Ayurvedic Medical College, Guwahati, Assam, India were included in the study, and randomly divided into 2 groups, GlucoCare and placebo. All received either GlucoCare or placebo in a dose of 2 capsules twice daily, before meals for 3 months. All 50 patients completed the study - no drop outs, withdrawals or patients lost to follow up. The GlucoCare group showed significant improvement in symptoms from the 2nd month till the end of the study. GlucoCare was well tolerated by all patients throughout the treatment period with no evidence of adverse effects. The study indicates clinical efficacy of GlucoCare Capsules in the management of NIDDM in those belonging to pitta-kapha prakriti. The formulation is well tolerated and appears safe in the dosage used.