ABSTRACT
To examine the possible pathophysiologic role of protein C-a natural anticoagulant- in thromotic and embolic cerebrovascular strokes, we studied 20 patients with acute stroke [10 subjects with thrombotic stroke, and 10 others with embolic stroke]. Prothrombin time, activated partial thromboplastin time [APTT], plasma fibrinogen, plasma protein C activity, and serum fibrin [ogen] degradation products [FDP[s]] were measured in these subjects and were compared to those in 10 healthy volunteers. Prothrombin time and APTT were comparable in all groups. Plasma fibrinogen and serum FDP[s] were significantly increased, and plasma protein C activity was significantly diminished in the thrombotic and embolic stroke patients in comparison to healthy individuals. Although these hemostatic alterations can be secondary to thrombin generation in thrombotic and embolic strokes, yet they may share in the initiation or perpetuation of the pathophysiologic process involved in the genesis of these strokes
Subject(s)
Humans , Male , Female , AnticoagulantsABSTRACT
The present study was carried out on 20 male albino rats divided into two groups. Sham operated control [10 rats] in which the ureter was visualized but not ligated. The other group [10 rats] the animals were exposed to unilateral obstruction for 48 hours after which blood samples were collected, and both kidneys in each rat were removed. In the unilateral ureteral obstruction group, significant decrease of kidney tissue levels of Na + and K + as well as significant decrease of Na + - K + ATPase activity in kidney cortex and outer medulla tissue homogenate with nonsignificant changes in plasma Na + and K + levels were detected as compared to contralateral kidney and sham operated control group. While, in the contralateral kidney, cortex and outer medulla homogenate and insignificant changes of kidney tissue K + were detected as compared to sham operated control group. Results were fully discussed
Subject(s)
Ureteral Obstruction , RatsABSTRACT
The present work was undertaken to record the effect of some central depressant drugs and neurotransmitters on EEG and O2 uptake of normal rat brain. EEG changes of rat brain under the influence of some uremic toxins were also determined. Phenobarbitone, diazepam and chlorpromazine caused significant damping of EEG amplitude and O2-uptake of the normal rat brain. The neurotransmitter acetyl choline resulted in a significant diminution of both EEG amplitude and O2-uptake, while atropine sulphate did not change both. Serotonin caused significant caused significant reduction of O2-uptake of rat brain tissue, while epinephrine increased it significantly as compared to controls. Uremic toxins, urea, uric acid, phenol, ethanolamine and 5-hydroxy indol acetic acid reduced significantly EEG amplitude of rat without changes in frequency, except creatinine which did not result in any significant changes. Similarity between the mode of action of both uremic endotoxins and depressant drugs through central neurotransmitters was suggested. Results were fully discussed
Subject(s)
Oxygen Consumption , Electroencephalography , RatsABSTRACT
The preset trial was carried out to detect the presence of platelet antibodies and to assess serum immunoglobulins in schistosomiasis before and after splenectomy. The study included 50 male cases with schistosomal hepatosplenomegaly and 10 normal male subjects as controls. Splenectomy was performed in 10 cases showing evidences of hypersplenism. Moderate thrombocytopenia was observed in all schistosomal cases. Platelet antibodies were detected in 30% of schistosomal cases associated with marked thrombocytopenia. Serum immunoglobulin G and M were significantly increased in bilharzial patients as compared to controls, which was more pronounced in respect to IgG in cases having platelet antibodies. Following splenectomy, significant increase of platelet count and significant reduction of platelet antibodies were found without any associated changes in serum immunoglobulins. Results were fully discussed
Subject(s)
Blood Platelets , Immunoglobulins , SplenectomyABSTRACT
The effect of cigarette smoke exposure and high salt intake, either singly or in combination, were assessed on some atherogenic factors. Significant increases in total cholesterol were found in all treated groups. When combined cigarette smoke exposure and high salt intake had an additive effect. This was combined with a lack of effect on HDL cholesterol. Cigarette smoke exposure resulted in a 28% increase in serum triglycerides. Although high salt intake alone was without effect on this parameter, it had a synergistic effect when combined with cigarette smoke exposure. Platelet aggregation was significantly increased after cigarette smoke exposure, high salt diet intake and their combination. Significant decrease of prothrombin time and partial thromboplastin time were recorded after high salt intake and its combination with cigarette smoke exposure, which may denote increase tendency for thrombus formation. Results were fully discussed
Subject(s)
Smoking , Sodium Chloride , RabbitsABSTRACT
The research was planned to study the gingival condition of diabetics clinically, to estimate gingival tissue respiration in diabetes and to clarify the effect of severity of the disease of the gingiva. Present results revealed an increase in the pocket depth, loss of attachment and tooth mobility in the diabetic groups [controlled and uncontrolled diabetics] as compared with the non-diabetic persons. There is an increase in the gingival index in the diabetic group. The oxygen consumption of the gingival tissue of the controlled and uncontrolled diabetics was significantly decreased as compared to that of the non-diabetic subjects. Explanation of these results was discussed and explained