ABSTRACT
Background: The study was conducted in the Urban slum area, Shekpet, Hyderabad, India which is the field practice area of Apollo Medical college.Methods: The aims was to study the awareness regarding symptoms, mode of spread and preventive measures of swine flu in the study population and to study the sources of information and health care seeking pattern of the population. Pre-designed questionnaire was used to collect information onsocio -demographic characteristics (age, sex, education and occupation), knowledge and awareness about the disease (nature, mode of spread/transmission, clinical features, preventive measures and precautions).Results: Majority were unaware of spread of Swine Flu from Pigs. 32% of them said it spreads through coughing and 27% through sneezing. About 15% of them said it spreads by sharing same room.Conclusions: The cross sectional study, was taken up during the recent outbreak of Swine flu in Hyderabad. Knowledge, Attitude and Prevention practices of the infection, was carried out in the urban slum of Shaikpet area the study will create awareness of the disease and its preventive measures among the people. Thus, it would reduce the incidence of occurrences of the disease in future.
ABSTRACT
Objective: To develop and characterize multiple-unit-type oral floating microsphere of famotidine to prolong gastric residence time and to target stomach ulcer. Methods: The floating microspheres were prepared by modified solvent evaporation method. Eudragit S-100 was used as polymer. Microspheres were characterized for the micromeritic properties, floating behavior, entrapment efficiency and scanning electron microscopy. The in-vitro release studies and floating behavior were studied in simulated gastric fluid at pH 1.2. Different drug release kinetics models were also applied for all the batches. Selected formulations were also subjected for X-ray radiographic study. Results: Floating microspheres were successfully prepared by modified solvent evaporation technique. Microspheres showed passable flow properties. The maximum yield of microspheres was up to (95.11±0.35)%. On the basis of optical microscopy particle size range was found to be ranging from (52.18±182.00) to (91.64±5.16) μm. Scanning electron microscopy showed their spherical size, perforated smooth surface and a cavity inside microspheres. Microspheres were capable to float up to 20 h in simulated gastric fluid. X-ray radiographic studies also proved its better retention in the stomach. Conclusions:On the basis of the results, such dosage forms may be a good candidate for stomach targeting and may be dispensed in hard gelatin capsules.
ABSTRACT
The antiulcer activity of the aerial parts of Mirabilis jalapa Linn. [fam. Nyctaginaceae] was studied on albino rats. The antiulcer activity of the chloroform extract, ethanolic extract and aqueous extract was evaluated by using pyloric ligation models and alcohol induced ulceration model. All the test samples revealed significant antiulcer activity. The order of decreasing ulcer score was found to be aqueous extract < ethanol extract < chloroform extract in all performed models. The results indicate that the aerial parts of Mirabilis jalapa are endowed with potential antiulcer activity