Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional study

ABSTRACT BACKGROUND: The prevalence of chronic kidney disease (CKD) has increased in the recent decades, along with the number of patients in the terminal stages of this disease, requiring transplantation. Some skin disorders are more frequent in patients with CKD and in renal transplant recipients (RTR). OBJECTIVES: To evaluate the frequency of skin diseases in RTR and patients with CKD receiving conservative treatment. DESIGN AND SETTING: This observational cross-sectional study recruited consecutive patients with CKD and RTR from a nephrology clinic at a teaching hospital in Brazil between 2015 and 2020. METHODS: Quantitative, descriptive, and analytical approaches were used. The sample was selected based on convenience sampling. Data were collected from dermatological visits and participants' medical records. RESULTS: Overall, 308 participants were included: 206 RTR (66.9%, median age: 48 years, interquartile range [IQR] 38.0-56.0, 63.6% men) and 102 patients with CKD (33.1%, median age: 61.0 years, IQR 50.0-71.2, 48% men). The frequency of infectious skin diseases (39.3% vs. 21.6% P = 0.002) were higher in RTR than in patients with CKD. Neoplastic skin lesions were present in nine (4.4%) RTR and in only one (1.0%) patient with CKD. Among the RTR, the ratio of basal cell carcinoma to squamous cell carcinoma was 2:1. CONCLUSIONS: This study revealed that an increased frequency of infectious skin diseases may be expected in patients who have undergone kidney transplantation. Among skin cancers, BCC is more frequently observed in RTR, especially in those using azathioprine.

Influência da composição corporal durante a hospitalização sobre a função pulmonar e força da musculatura inspiratória em pacientes com COVID-19: estudo transversal / Influence of body composition during hospitalization on lung function and inspiratory muscle strength in patients with COVID19: cross-sectional study

Introdução: Cerca de 31% dos pacientes hospitalizados com COVID-19 perdem mais de 5% de seu peso inicial, levando a fraqueza muscular. Portanto, a composição corporal tornou-se foco de investigação, para estimar comprometimento pulmonar, força da musculatura inspiratória e mortalidade. Objetivos: Investigar se a perda de peso e a composição corporal de pacientes internados com COVID-19 influenciam na função pulmonar e na força muscular inspiratória após alta hospitalar. Métodos: Estudo transversal. Pacientes adultos foram avaliados após internação por COVID-19. Os desfechos avaliados foram função pulmonar, pressão inspiratória máxima (Pimáx), composição corporal e mortalidade. As correlações entre as variáveis foram estimadas pelo Coeficiente de Correlação de Pearson. Resultados: A capacidade Vital Forçada (CVF) foi correlacionada com perda de peso, massa muscular esquelética, massa magra, perna esquerda e massa livre de gordura; o volume expiratório forçado no primeiro segundo (VEF1) correlacionou-se apenas com a perda de peso; e a Pimáx foi correlacionada com massa muscular esquelética, massa magra, perna esquerda, perna direita e massa livre de gordura. Conclusão: Observou-se correlação moderada entre CVF e as variáveis de composição corporal analisadas, exceto massa magra da perna esquerda; entre VEF1 e perda de peso; e entre Pimáx e as variáveis de composição corporal analisadas, exceto perda de peso.

Influence of awake bruxism behaviors on fatigue of the masticatory muscles in healthy young adults

Abstract The present cross-sectional study aimed to analyze the relationship between awake bruxism and fatigue of masticatory muscles in healthy young adults. For this purpose, 121 graduate students participated in this study. Frequency of awake bruxism was collected for 7 consecutive days by ecological momentary assessment (EMA) using an online survey (mentimeter). Muscle fatigue was tested one day after EMA assessment, which consisted of voluntarily and continuously clenching at 30% (kgf/cm2) of maximum bite force (MBF) until exhaustion. The percentage of change in MBF after the clenching task, as compared to the MBF before the clenching task was measured. The average frequency of awake bruxism was 45.5% during 7 days. Sustained clenching resulted in a significant reduction in MBF values in the total sample (p < 0.05). Nevertheless, no significant correlation was found between frequency of awake bruxism behaviors and percent of change in MBF and endurance time during the fatigue test. Therefore, it can be concluded that young healthy adults present a relatively high frequency of awake bruxism behaviors that do not seem to impact the degree of masticatory muscle fatigue.

Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury

BACKGROUND Dengue is a disease caused by dengue virus (DENV-1 through -4). Among the four serotypes, DENV-4 remains the least studied. Acute kidney injury is a potential complication of dengue generally associated with severe dengue infection. OBJECTIVES The goal of this study was to investigate the alterations caused by experimental dengue infection in the kidney of adult BALB/c mice. METHODS In this study, BALB/c mice were infected through the intravenous route with a DENV-4 strain, isolated from a human patient. The kidneys of the mice were procured and subject to histopathological and ultrastructural analysis. FINDINGS The presence of the viral antigen was confirmed through immunohistochemistry. Analysis of tissue sections revealed the presence of inflammatory cell infiltrate throughout the parenchyma. Glomerular enlargement was a common find. Necrosis of tubular cells and haemorrhage were also observed. Analysis of the kidney on a transmission electron microscope allowed a closer look into the necrotic tubular cells, which presented nuclei with condensed chromatin, and loss of cytoplasm. MAIN CONCLUSIONS Even though the kidney is probably not a primary target of dengue infection in mice, the inoculation of the virus in the blood appears to damage the renal tissue through local inflammation.

Avaliação do perfil clínico-terapêutico e da resposta à profilaxia dos portadores de hemofilia A e B em um centro de referência no Ceará / Evaluation of the clinical-therapeutic profile and the response to prophylaxis of patients with hemophilia A and B in a reference center in Ceará

Objetivo: Avaliar o perfil clínico-terapêutico e a resposta à profilaxia em pacientes hemofílicos A e B em um centro de referência no Ceará. Métodos: Estudo de coorte retrospectivo, com dados de 133 hemofílicos A e B, em profilaxia entre 2016 e 2021, por meio de prontuários médicos e sistema Web Coagulopatias. Resultados: Os pacientes todos do sexo masculino em sua maioria foram hemofílicos A (93,2%), na forma grave, residentes em Fortaleza, com maior prevalência do município de Guaiúba. A maioria fazia uso de Fator VIII recombinante e em profilaxia secundária, em relação ao comprometimento articular a maioria não apresentou relato de hemartroses (66,9%), articulação-alvo (87,9%) ou artropatia (54,9%), porém os hemofílicos em profilaxia terciária apresentaram um maior comprometimento articular em relação a profilaxia primária e secundária. Verificou-se uma correlação negativa entre o tempo de profilaxia e a dose de fator utilizada, demonstrando que quanto maior o tempo de profilaxia menor a dose do fator utilizada. Um total de 13 hemofílicos A grave desenvolveram inibidor de fator VIII realizando imunotolerância (ITI) com sucesso total em 84,6%. Por meio da curva ROC, foi verificado uma associação entre a necessidade de ITI e a dose de fator de coagulação, com acurácia de 67,7% de que o uso de doses maiores de fator predispõe ao desenvolvimento de inibidores. Conclusão: Os dados do estudo permitem inferir que quanto mais precoce o tratamento de profilaxia menor é comprometimento articular, dose do fator utilizada e menor predisposição de desenvolver inibidores dos fatores da coagulação.

Objective: to evaluate the clinical-therapeutic profile and response to prophylaxis in hemophiliac A and B patients at a referral center in Ceará. Methods: Retrospective cohort study, with data from 133 hemophiliacs A and B, undergoing prophylaxis between 2016 and 2021, using medical records and the Web Coagulopathies system. Results: Most of the patients were male patients with severe hemophilia A (93.2%), residing in Fortaleza, with a higher prevalence in the city of Guaiúba. Most made use of recombinant Factor VIII and in secondary prophylaxis, in relation to joint involvement, the majority did not report hemarthroses (66.9%), target joint (87.9%) or arthropathy (54.9%). however, hemophiliacs on tertiary prophylaxis showed greater joint impairment in relation to primary and secondary prophylaxis. There was a negative correlation between the prophylaxis time and the factor dose used, demonstrating that the longer the prophylaxis time, the lower the factor dose used. A total of 13 severe A hemophiliacs developed factor VIII inhibitor performing immunotolerance (ITI) with total success in 84.6%. Using the ROC curve, an association was verified between the need for ITI and the dose of coagulation factor, with an accuracy of 67.7% that the use of higher doses of factor predisposes to the development of inhibitors. Conclusion: The study data allow us to infer that the earlier the prophylaxis treatment, the less joint impairment, the dose of the factor used and the less predisposition to develop coagulation factor inhibitors.

LEAF ANATOMY CHARACTERIZATION OF FOUR Apochloa SPECIES: A C3 GENUS RELATED TO EVOLUTION OF C4 PATHWAY IN GRASSES / Caracterización anatómica de hojas de cuatro especies de Apochloa: un género relacionado con la evolución de la vía C4 en gramíneas

ABSTRACT Leaf anatomy characteristics provide important evidences about the transition between C3 and C4 pathways. The C4 photosynthesis pathway allowed to reduce the C3 photorespiratory rate, concentrating CO2 around the Rubisco site and using structures and machinery already presented in C3 plants. In monocots, it is observed a high number of C4 lineages, most of them phylogenetically related to C3 groups. The genus Apochloa (C3), subtribe Arthropogoninae, is related to two C4 genera Coleataenia and Cyphonanthus. The aim of this study was to evaluate four Apochloa species in order to establish anatomical characteristics related to the evolution of C4 pathway in this group. By means of transverse sections fully expanded leaves of A. euprepes, A. lorea, A. molinioides, and A. poliophylla were collected and the characteristics of the mesophyll (M) and bundle sheath (BS) cells were determined. These species showed a rustic Kranz anatomy with enlarged and radial arranged BS cells, which have few organelles organized in a centrifugal position. Although the modifications of BS cells are probably related to the maintenance of plant water status, we also discuss the evolution for the establishment of C4 photosynthesis in the related C4 genera.

RESUMEN Las características de la anatomía de la hoja proporcionan evidencias importantes sobre la transición entre las vías C3 y C4. La fotosíntesis C4 surgió para reducir la tasa de fotorrespiración C3, concentrando el CO2 alrededor del sitio de la Rubisco y utilizando estructuras y maquinaria ya presentes en las plantas C3. En monocotiledóneas, se observa un alto número de linajes C4, la mayoría de ellas filogenéticamente relacionadas con grupos C3. El género C3 Apochloa, que pertenece a la subtribu Arthropogoninae, está relacionado con dos géneros C4 Coleataenia and Cyphonanthus. En este contexto, el objetivo fue evaluar cuatro especies de Apochloa para establecer las características anatómicas relacionadas con la evolución de la via C4 en este grupo. Se colectaron hojas completamente expandidas de A. euprepes, A. lorea, A. molinioides y A. poliophylla y se determinaron las características de las células del mesófilo (M) y del haz de la vaina (HV) a partir de secciones transversales de la hoja. Las especies presentaron una anatomía rústica de Kranz con células HV agrandadas y de distribución radial, con pocas organelas organizadas en posición centrífuga. Aunque las modificaciones de las células HV están probablemente relacionadas con el mantenimiento del estado hídrico de la planta, se puede inferir que facilitan el establecimiento de la fotosíntesis en los géneros C4 relacionados.

A Review on COVID-19 Diagnosis Tests Approved for Use in Brazil and the Impact on Pandemic Control

Abstract With the COVID-19 pandemic, many diagnostic tests (molecular or immunological) were rapidly standardised, given the urgency of the situation, many are still in the process of being validated. The main objective of this study was to review the aspects of the diagnostic kits approved in Brazil and their application in the different federative units to gather epidemiological information. In order to achieve these objectives, a survey was carried out on the data available at the regulatory agency (ANVISA) and in the literature. The main countries that have registered products in Brazil are China (51.4%), Brazil (16.6%), South Korea (9.2%), USA (8.8%) and Germany (3.6%). The methodologies of these products are based on the detection of nucleic-acid (15.8%), antigen (13%) and antibody (71.2%). In the immunological tests, it was verified that the sensitivity ranged from 55 to 100% and the specificity from 80 to 100%. The percentage of cases in the samples tested in Brazil is elevated in almost all federative units since eight states showed 40% of positive cases in tested samples, while 18 states displayed between 20 and 40%. In conclusion, this review showed that Brazil is dependent on external technology to respond to pandemics, epidemics and endemics disease and needs to improve its biotechnological scheme to solve further diseases outbreaks.

Exploring spatial dependence of cowpea-beans yield using global and local autocorrelation statistics in the Eastern Cariri region of Paraíba / Explorando a dependência espacial da produtividade do feijão-caupi usando estatísticas globais e locais de autocorrelação na região do Cariri oriental da Paraíba

ABSTRACT: This study evaluated the variability and characterizedthe spatial dependence between some soil attributes in the Eastern Cariri microregion of Paraíba,and analyzed the spatial correlations in order to identify the interactions between such attributes in cowpea bean(Vigna unguiculata L. Walp)production. Harvest data of the agricultural years of 2000-2017 in the Eastern Cariri microregion of Paraíba were analyzed. Parameters of the fitted models wereestimated using the Maximum Likelihood method and the performance of the models was evaluated based on coefficients of determination(R2), maximum log-likelihood function, and Schwarz's Bayesian information criterion (BIC). Correlation and spatial autocorrelation between the cowpea productivity and agrometeorological elements was detected through the spatial analysis, using techniques such as the Moran's index I. The study showed that, according to the performance indicators used, the spatial error model offered better results in relation to the classical multiple regression models and the self-regressive spatial models, indicating that the inclusion of spatial dependence in the models improves the estimate of productivity of cowpea in the microregion of Cariri Oriental da Paraíba.

RESUMO: O estudo tem por finalidade avaliar a variabilidade e caracterizar a dependência espacial entre alguns atributos dos solos na microrregião do Cariri Oriental da Paraíba, bem como estudar as correlações espaciais para identificar as interações entre tais atributos na produção do feijão-caupi. O estudo foi realizado com os dados das safras dos anos agrícolas de 2000-2017, da microrregião do Cariri Oriental da Paraíba. A estimativa de parâmetros dos modelos ajustados foi obtida utilizando o método de Máxima Verossimilhança e a avaliação do desempenho dos modelos foi realizada com base no coeficiente de determinação (R2), no máximo valor do logaritmo da função verossimilhança e no critério de informação bayesiano de Schwarz (BIC). Este estudo também permitiu verificar a correlação e autocorrelação espacial entre a produtividade do feijão e dos elementos agrometeorológicos, por meio da análise espacial, usando de técnicas como o índice I de Moran. O estudo mostrou que, de acordo com os indicadores de desempenho utilizados, o modelo de erro espacial ofereceu melhores resultados em relação aos modelos clássicos de regressão múltipla e aos modelos espaciais autorregressivos, indicando que a inclusão da dependência espacial nos modelos melhora a estimativa da produtividade do feijão-caupi em a microrregião do Cariri Oriental da Paraíba.

Botulinum toxin-A injections as therapy for chronic painful post-traumatic trigeminal neuropathy: case report / Injeções de toxina botulínica-A como terapia para dor neuropática trigeminal pós-traumática crônica: relato de caso

Painful post-traumatic trigeminal neuropathy (PTTN) involves spontaneous and evoked pain, of moderate to severe intensity, continuous and described as burning or shooting. The first line treatment is pharmacological. However, botulinum toxin - A (BoNT-A) can be used when medications cannot control pain. This article describes the use of BoNT-A in a case of PTTN refractory to conventional pharmacological treatment. A 44-year-old male patient presented with an 8-years history of pain in the lower left second molar region. Pain was burning, lasting for seconds, with multiple pain episodes per day. Diagnosis hypothesis was PTTN. After no improvement with conventional pharmacological treatment, injections of BoNT-A were elected. Somatosensory assessment showed a significant reduction in visual analog scale for touch, cold and pinprick sensitivity. Likewise, patient's impression of change in pain significantly improved after BoNT-A injections. Our results suggest that BoNT-A could be used as a treatment for PTTN refractory to conventional treatments. (AU)

A neuropatia trigeminal pós-traumática dolorosa (PTTN) envolve dor espontânea e evocada, de intensidade moderada a grave, contínua e descrita como queimante ou lascinante. O tratamento de primeira linha é farmacológico. No entanto, a toxina botulínica - A (BoNT-A) pode ser usada quando os medicamentos não conseguem controlar a dor. Este artigo descreve o uso da BoNT-A em um caso de PTTN refratário ao tratamento farmacológico convencional. Paciente de sexo masculino, 44 anos, com 8 anos de dor na região do segundo molar inferior esquerdo. A dor foi descrita como queimante, com duração de segundos e com vários episódios por dia. A hipótese de diagnóstico foi PTTN. Após nenhuma melhora com o tratamento farmacológico convencional, as injeções de BoNT-A foram eleitas. A avaliação somatossensorial mostrou uma redução significativa na escala visual analógica para sensibilidade ao toque, frio e picada após BoNT-A. Da mesma forma, a impressão de mudança do paciente na dor melhorou significativamente após as injeções de BoNT-A. Nossos resultados sugerem que o BoNT-A poderia ser usada como tratamento para PTTN refratário a tratamentos convencionais. (AU)

Are surface and deep learning approaches associated with study patterns and choices among medical students? A cross-sectional study

ABSTRACT BACKGROUND: Different approaches to learning can exert considerable influence on the teaching-learning process in medical education. This study aimed to investigate the association of surface and deep learning with study patterns, preferred type of assessment, practices of cheating and quality of sleep among medical students. DESIGN AND SETTING: Cross-sectional study on medical students enrolled in all six years of a medical school in Juiz de Fora, Brazil. METHODS: Questionnaires were applied to evaluate learning approaches (R-SPQ-2F), study patterns, sources and choices, and quality of sleep. Students' learning approaches (deep or surface) were assessed in relation to their study patterns, study resources, quality of sleep and whether they cheated in tests. RESULTS: Among the 710 students included, 43% frequently studied on the night before an exam, 65% had used psychostimulants to study and more than 46% had cheated in an exam. Regarding quality of sleep, most students (53.4%) reported that their quality of sleep was poor, such that 45.3% slept for fewer than five hours before an exam. Those who studied just prior to an exam, used class summaries, preferred multiple-choice questions and cheated during the test had a more surface-learning approach. On the other hand, those who read books, preferred practical exams and slept better had a deeper approach. CONCLUSION: The type of learning approach was associated with study patterns and choices among medical students. Educators need to be attentive to the type of learning their students use and think of measures that impact teaching and assessment methods.

Bilateral elastofibroma dorsi - rehabilitation of an uncommon tumor: case report / Elastofibroma dorsi bilateral - reabilitação num tumor incomum: relato de caso

Elastofibroma are rare, slow-growing, soft tissue benign tumors that originate from mesenchymal tissue. We report an 85-year-old male patient with the diagnosis of bilateral elastofibroma dorsi whose symptoms were bilateral chronic pain in the thoracic spine and limitation of shoulder range of motion. The proposed treatment consisted of a rehabilitation program in our department mainly focused on pain management and postural reeducation of the scapulohumeral rhythm, with great improvements namely on the anterior extension and abduction of the shoulder and with no pain at the 6-month post-treatment reevaluation. This shows an important role of Physical Medicine and Rehabilitation in the management of patients with these rare tumors.

Os elastofibromas são tumores raros benignos de tecidos moles, de crescimento lento, que se originam do tecido mesenquimatoso. Relatamos o caso de um paciente, do género masculino, 85 anos com diagnóstico de elastofibroma dorsi bilateral cujos sintomas apresentados eram dor crônica bilateral na coluna torácica e limitação da amplitude de movimento dos ombros. O tratamento proposto consistiu num programa de reabilitação no departamento de Medicina Física e de Reabilitação, focado principalmente no controlo da dor e na reeducação postural do ritmo escapuloumeral, com grandes melhorias, principalmente na extensão anterior e abdução do ombro e sem dor na reavaliação aos 6 meses após o tratamento. Pretendemos demonstrar o importante papel da Medicina Física e Reabilitação no manejo dos doentes acometidos por estes raros tumores.

Calibration and validation of the AquaCrop model for the soybean crop grown under different levels of irrigation in the Motopiba region, Brazil / Calibração e validação do modelo AquaCrop para a cultura de soja cultivada mediante diferentes níveis de irrigação na região de Matopiba, Brasil

ABSTRACT: The water-driven AquaCrop model to simulate yield response has been calibrated and validated for soybean cultivated under different water levels irrigation in Matopiba region, Brazil. The crop was submitted to seven irrigation treatments during the dry season and a dry treatment in the rainy season. The model was parameterized and calibrated by using soybean yield data collected at field level. Model performance was evaluated by using the following statistical parameters: prediction error (Pe), Nash-Sutcliffe efficiency index (E), coefficient of determination (R2), mean absolute error (MAE), root mean square error normalized (RMSEN) and Willmott's index (d). The statistical analyses of the AquaCrop model calibrated for the Matopiba region disclosed error acceptable for yield prediction of soybean grown under tropical climate conditions. Results also indicated that the C2 soybean cultivar is more resistant to water stress than the C1 soybean grown in the Matopiba region, Brazil. In the treatments when the crop was well supplied with water, at least in one phase, the yield was greater than those with drought stress at last in one phase.

RESUMO: O modelo AquaCrop foi calibrado e validado para simular a produtividade da soja cultivada sob diferentes lâminas de irrigação na região de Matopiba, Brasil. A cultura foi submetida a sete tratamentos de irrigação durante a estação seca e um tratamento de sequeiro na estação chuvosa. O modelo foi parametrizado e calibrado utilizando dados de produtividade de soja coletados diretamente em campo. O desempenho do modelo foi avaliado utilizando os seguintes parâmetros estatísticos: erro de predição (Pe), índice de eficiência de Nash-Sutcliffe (E), coeficiente de determinação (R2), erro médio absoluto (EMA), raiz quadrática do erro médio normalizado (EQEMN) e índice de Willmott (d). As análises estatísticas do modelo AquaCrop calibrado para a região de Matopiba apresentaram erros aceitáveis na predição da produtividade de soja cultivada sob condições climáticas tropicais. Os resultados também indicaram que a cultivar de soja C2 é mais resistente ao estresse hídrico do que a soja C1 cultivada na região de Matopiba, Brasil. Nos tratamentos durante os quais a cultura foi bem abastecida com água, em pelo menos em uma fase, a produtividade foi maior, em vista do estresse hídrico que ocorre em uma fase.

Ecophysiological, anatomical and ultrastructural characteristics of Vitex polygama Cham. (Verbenaceae) submitted to different concentrations of fluoride / Características ecofisiológicas, anatômicas e ultraestruturais de Vitex polygama Cham. (Verbenaceae) submetida a diferentes concentrações de flúor

Fluorides released during the manufacture of aluminum, fertilizers, glass and ceramics are considered to be highly toxic to plants, causing damages in relatively small concentrations. This study aimed to evaluate fluoride (F) accumulation and its effects on Vitex polygama Cham. (Verbenaceae) exposed to simulated rain containing potassium fluoride in concentrations of 5, 10, 15 and 20 mg L-1. Vitex polygama presented no visual symptoms of foliar injury and accumulated a relatively small amount of F-, significant only for the treatments with higher concentrations of the pollutant. F- promoted an increase in non-photochemical quenching (qN) and in the coefficient due to non -photochemical extinction (NPQ), which indicates higher dissipation of radiant energy in the heat form. Damages in the chloroplast structure, in cellular membranes and in epicuticular waxes, besides cytoplasm granulation and irregularities in the epidermal cell walls were also detected in plants exposed to the pollutant. The results show a considerable resistance of Vitex polygama to F and reinforce the prognostic value of physiological, anatomical and ultrastructural analysis in the detection of damages caused by the pollutant in the leaf structure of this species.

Fluoretos, liberados durante a manufatura de alumínio, fertilizantes, vidro e cerâmica, são considerados altamente tóxicos para as plantas, causando danos em concentrações relativamente pequenas. Este estudo teve como finalidade avaliar o acúmulo de flúor (F) e seus efeitos sobre Vitex polygama Cham. (Verbenaceae) em plantas expostas a chuva simulada contendo fluoreto de potássio em concentrações de 5, 10, 15 e 20 mg L-1. Vitex polygama não apresentou sintomas visíveis de injúria foliar e acumulou uma quantidade relativamente pequena de F-, significativa apenas para os tratamentos com maiores concentrações do poluente. O F- promoveu aumentos no coeficiente devido à extinção não fotoquímica (qN) e no coeficiente devido à extinção não fotoquímica (NPQ), que indicam maior dissipação de energia radiante na forma de calor. Danos na estrutura dos cloroplastos, em membranas celulares e nas ceras epicuticulares, além de granulação do citoplasma e irregularidades na parede celular de células epidérmicas, foram também detectados em plantas expostas ao poluente. Os resultados demonstram uma considerável resistência de Vitex polygama ao F e reforçam o valor prognóstico de análises fisiológicas, anatômicas e ultraestruturais na detecção de danos causados pelo poluente na estrutura foliar dessa espécie.

Validação do Nursing Activities Score em unidades de cuidados intensivos portuguesas / Validación del Nursing Activities Score en unidades de cuidados intensivos portuguesas / Validation of the Nursing Activities Score in Portuguese intensive care units

RESUMO Objetivo: descrever o processo de adaptação e validação do Nursing Activities Score para o contexto português. Método: trata-se de um estudo-piloto de adaptação e validação do Nursing Activities Score, com amostra de 67 doentes internados em unidades de cuidados intensivos de três hospitais portugueses. A validade de constructo avaliou-se mediante procedimentos de análise fatorial e a consistência interna dos itens através do coeficiente Alpha de Cronbach. Resultados: obteve-se um valor médio da carga de trabalho de 63,04% (DP = 14,25; Mediana = 61,30). Os dados psicométricos revelaram um Alpha de Cronbach de 0,71, na escala total, indicando uma fidelidade aceitável. A análise fatorial confirmatória sugeriu um ajustamento adequado entre o modelo e os dados (χ2(199) = 214,5, p = 0,214; CFI = 0,95; RMSA = 0,035). Conclusão: neste estudo, a versão portuguesa do Nursing Activities Score revelou-se um instrumento válido, permitindo avaliar a carga de trabalho dos enfermeiros com segurança.

RESUMEN Objetivo: describir el proceso de adaptación y validación del Nursing Activities Score al contexto portugués. Método: estudio piloto de adaptación y validación del Nursing Activities Score, con muestra de 67 pacientes internados en unidades de cuidados intensivos de tres hospitales portugueses. La validez del constructo se evaluó mediante análisis factorial y por consistencia interna de los ítems evaluados a través del coeficiente Alpha de Cronbach. Resultados: se obtuvo un valor medio de carga de trabajo de 63,04% (SD=14,25; Mediana=61,30). Los datos psicométricos expresaron un Alpha de Cronbach de 0,71 en la escala total, indicando fidelidad aceptable. El análisis factorial confirmatorio sugirió un ajuste adecuado entre el modelo y los datos (χ2(199)=214,5; p=0,214; CFI=0,95; RMSA=0,035). Conclusión: en este estudio, la versión portuguesa del Nursing Activities Score demostró ser un instrumento válido, permitiendo evaluar la carga de trabajo de los enfermeros con precisión.

ABSTRACT Objective: to describe the process of adaptation and validation of the Nursing Activities Score to the Portuguese context. Method: this was a pilot study of adaptation and validation of the Nursing Activities Score with a sample consisting of 67 patients hospitalized in the intensive care units of three Portuguese hospitals. The construct validity was assessed through factor analysis procedures and the internal consistency of the items was measured through the Cronbach's alpha coefficient. Results: a mean workload value of 63.04% (SD = 14.25; Median = 61.30) was obtained. Psychometric data revealed a Cronbach's alpha of 0.71 in the total scale, indicating an acceptable accuracy. Confirmatory factor analysis suggested an appropriate adjustment between the model and the data (χ2(199) = 214.5, p = 0.214; CFI = 0.95; RMSA = 0.035). Conclusion: in the present study, the Portuguese version of the Nursing Activities Score was found to be a valid instrument, enabling a safe assessment of the workload of nurses.

Millet and corn oil in sorghum-based diets for broilers / Milheto e óleo de milho em dietas a base de sorgo para frangos de corte

ABSTRACT:This study evaluated the effects of millet and corn oil additions to sorghum-based diets on the performance, carcass yields and prime cuts (i.e., wings, breasts, thighs and drumsticks) and the relative weights of edible offal (i.e., gizzard, heart, and liver) of broiler chickens. A total of 684 Hubbard Flex chickens, including 342 broilers of each sex, were housed. The design was completely randomized, and the following diets were supplied: A) sorghum and soybean meal + soybean oil (control); B) sorghum and soybean meal + corn oil; and C) sorghum and soybean meal + millet and soybean oil. Six replicates with 38 birds each (19 males and 19 females) were evaluated regarding each experimental diet. At 14, 21, 35 and 42 days of age, the feed intake, weight gain, feed conversion and viability of the chickens were evaluated. At 42 days, the live weight, carcass yield, prime cuts and relative weight of the edible offal were measured. The dietary inclusion of either millet or corn oil did not affect any of the parameters. In conclusion, additions of millet and corn oil to sorghum-based diets of broilers do not compromise poultry performance.

RESUMO:Objetivou-se avaliar os efeitos da inclusão de milheto e óleo de milho em dietas a base de sorgo sobre o desempenho, rendimento de carcaça e de cortes nobres (asas, peito, coxa e sobrecoxa) e peso relativo das vísceras comestíveis (moela, coração e fígado) de frangos de corte. Foram alojadas 684 aves, sendo 342 de cada sexo, da linhagem Hubbard Flex. O delineamento foi inteiramente casualisado, composto pelas dietas: A) sorgo+farelo de soja/óleo de soja (controle), B) sorgo+farelo de soja/óleo de milho e C) sorgo+farelo de soja/milheto+óleo de soja. Cada dieta experimental foi avaliada em seis repetições de 38 aves cada (19 machos e 19 fêmeas). Aos 14, 21, 35 e 42 dias de idade das aves, avaliou-se o consumo de ração, ganho de peso, conversão alimentar e viabilidade. Aos 42 dias, foi obtido o peso vivo, rendimento de carcaça e de cortes nobres, além do peso relativo das vísceras comestíveis. A inclusão de milheto ou óleo de milho nas dietas não alterou nenhum dos parâmetros avaliados. Concluiu-se que, em dietas a base de sorgo para frangos de corte, o milheto e o óleo de milho podem ser adicionados sem comprometer a produtividade das aves.

LACLAU, SEXUALIDADES E OS CORPOS: ANÁLISE DAS SUBJETIVAÇÕES URSINAS / LACLAU, SEXUALIDADES Y LOS CUERPOS: ANÁLISIS DE SUBJETIVACIONES OSINAS / LACLAU, SEXUALITIES AND THE BODIES: ANALYSIS OF BEAR SUBJECTIFICATIONS

Este artigo traz o debate dos corpos para analisar subjetivações ursinas. Inicialmente, é delineada uma breve revisão conceitual de analíticas de poder que contribuem para os estudos em embodiments, com destaque para Laclau e Mouffe (1987), Butler (2010) e Michel Foucault (1996). Foi realizada uma pesquisa qualitativa e corpus de pesquisa foi produzido por meio de entrevistas individuais semiestruturadas com 19 participantes. Os dados foram analisados sob a ótica pós-estruturalista do discurso tendo em vista as abordagens laclauniana e foucaultiana. A pesquisa conclui que o discurso ursino sobredetermina práticas dispersas no campo de afetividades analisado ao articular um esquema corpóreo "masculino". Este esquema se assume como um ponto nodal e, consequentemente, é o primeiro a ser acionado nas subjetivações dos participantes. Porém, tal processo não se concretiza de forma plena, nem elimina particularidades que muitas vezes parodiam demandas comportamentais...

Este artículo aporta al debate de los cuerpos para analizar subjetivaciones osinas. Inicialmente, es delineada una breve revisión conceptual de analícticas del poder que contribuyen a los estudios en embodiments, especialmente por Laclau y Mouffe (1987), Butler (2010) y Michel Foucault (1996). Se llevó a cabo una investigación cualitativa y el corpus de investigación fue producido a través de entrevistas individuales semiestructuradas con 19 participantes. Los datos fueron analizados a partir de la perspectiva postestructuralista del discurso dada las analícticas laclauniana y foucaultiana. La investigación concluye que el discurso osino sobredetermina prácticas dispersas en el campo de afectividades analizado mediante la articulación de un esquema corporal "masculino". Este esquema se configura en un punto nodal y por lo tanto es primero en ser despedido en los procesos de subjetivaciones. Sin embargo, esto proceso no se realiza plenamente, ni elimina particularidades que a menudo parodian demandas comportamentales...

This article brings the debate of bodies to analyze processes of subjectification of gay men called bears. Initially it's outlined a brief conceptual review of analytics of power that contribute to studies of embodiments, especially by Laclau and Mouffe (1987), Judith Butler (2010) and Michel Foucault (1996). The article is based on a qualitative research and the data were collected through semi-structured individual interviews with 19 participants. The data were analyzed considering the poststructuralist perspective of discourse studies given the Laclaudian and Foucauldian approaches. The research concludes that the bear discourse overdetermines dispersed practices in a field of affectualities by constructing a "masculine" body scheme. This scheme is a nodal point and therefore is the first to be enacted on subjectification processes. However, these processes are not fully realized, neither eliminates particularities that often parody the behavioral demands...

Telas agrícolas como subcobertura no cultivo de alface hidropônica / Agricultural nets as undercover in hydroponic cultivation of lettuce

Este trabalho teve como objetivo avaliar o efeito de diferentes tipos de telas de sombreamento utilizadas como subcobertura no cultivo hidropônico de alface. Para isso, foi conduzido um experimento em estufas cobertas com filme plástico de 150µm com três tipos de subcobertura: tela termorrefletora, preta, vermelha e um ambiente controle sem o uso de tela. Para avaliar a modificação ambiental ocasionada pelos tratamentos, foram instalados em cada estufa e no ambiente externo um termohigrômetro data logger, que registrou a temperatura a cada 15 minutos do dia 18/05/2011 ao dia 14/06/2011. Posteriormente, foram calculados os graus-dia acumulados em cada ambiente. Para analisar as variações de crescimento das plantas nas diferentes condições de cultivo, foram realizadas cinco coletas ao longo do período experimental. Após a coleta das plantas, elas eram levadas ao laboratório para contagem do número de folhas maiores que 10cm de comprimento e para a determinação do índice de área foliar. Os resultados indicaram que o uso das telas alterou os padrões da temperatura, quando o uso das telas termorrefletora e preta reduziu a temperatura máxima em 4,7 e 3,6ºC, respectivamente, em relação ao ambiente controle, permitindo um menor acúmulo térmico no período experimental. Quanto às alterações morfológicas ocasionadas pelas modificações ambientais, foi possível constatar que o uso das telas termorrefletora e preta aumentou o número de folhas maiores que 10cm e o índice de área foliar. O uso de tela preta ou termorrefletora como subcobertura em estufas pode ser uma alternativa viável para incrementar a produção de alface em condições tropicais.

This study aimed to evaluate the effect of different types of shading nets used as undercover of plastic in greenhouses of hydroponic cultivation of lettuce. The experiment was performed in greenhouses covered with plastic film of 150µm with three types of undercover nets: thermal reflector net, black, red and acontroltreatment - without the use of the undercover.To evaluate the environmental changes caused by treatments thermohygrometer data logger swere installed in each greenhouse as well asone in the external environment. The devices recorded the air temperature every 15 minutes from May 18th2011to June 14th2011. By using these data, it was possible to estimate the values of the growing degree-daysineach environment. To analyze the changes in plant growth and development caused by the treatments, five samples were taken along the experimental period. Inthe laboratorywe counted the number of leaves greater than 10cmof lengthand measured the leaf area index. The results indicated that the use of the nets changed the overall patterns of temperature and relative humidity. The use of thermal reflector net and black net reduced the maximum temperature at 4.7 and 3.6°C, respectively, compared to the controlalso allowing for lower growing degree-days at the end of the experimental period.As for the morphological changes caused by treatments, we observed that the use of thermal reflector netand black net increased the number of leaves greater than 10cm andalso the leaf area index.The use of black net or thermal reflector net as undercover in greenhouses can be a feasible alternative to increase the production of lettuce in tropical conditions.

Adjuvant Effect of IV Clodronate on the Delay of Bone Metastasis in High-Risk Prostate Cancer Patients: A Prospective Study / Journal of the Korean Cancer Association, 대한암학회지

PURPOSE: High-risk prostate cancer patients undergoing treatment often experience biochemical recurrence. The use of bisphosphonates as an adjuvant treatment delays skeletal events, yet whether or not bisphosphonates also delay metastastic development remains to be determined. MATERIALS AND METHODS: A total of 140 high-risk prostate cancer patients who were undergoing definitive treatment and who had clinically organ-confined disease and who suffered from biochemical recurrence were administered intravenous (IV) clodronate. The patients were treated with a radical retropubic prostatectomy (RP) or curative radiotherapy (RTx). Upon androgen deprivation therapy initiation, tri-monthly IV clodronate was added to the treatment to prevent bone demineralization. Twenty-six out of 60 operated cases and 45 out of 80 irradiated cases received bisphosphonate. The length of time until the first bone metastasis was recorded and analyzed. RESULTS: No statistical difference was found for the type of primary treatment (RP or RTx) on the time to the first bone metastasis (95% confidence interval [CI], 0.40 to 2.43; p=0.98). However, there was a clear advantage favoring the group that received bisphosphonate (p<0.001). The addition of bisphosphonate delayed the appearance of the first bone metastasis by seven-fold (95% CI, 3.1 to 15.4; p<0.001). CONCLUSION: Treatment with tri-monthly IV clodronate delayed the time to the first bone metastasis in high-risk prostate cancer patients who were experiencing an increase in the prostate specific antigen level after definitive treatment.

Relação entre níveis de ansiedade-traço competitiva e idade de atletas de voleibol e análise destes níveis pré e pós-competição / Relationship between levels of competitive anxiety and age of volleyball athletes and analyze of these levels pre and post-competition

O objetivo do estudo foi analisar os níveis de ansiedade traço-competitivo pré e pós- competição em jogadoras de voleibol e ainda, verificar a associação destes níveis com a idade destas atletas. Durante uma competição, 12 atletas de voleibol do sexo feminino (21,5 ± 2,9 (15-24) anos) responderam a Escala de Ansiedade Traço-Competitivo (SCAT) antes do início da partida e imediatamente após o término desta. Os resultados demonstraram que após a competição houve uma redução significativa dos valores de ansiedade traço-competitivo nas atletas de voleibol (p=0,01) e que há uma correlação significativa em que atletas mais jovens apresentaram níveis mais elevados de ansiedade traço-competitivo antes do início do jogo (p=0,001; r=0,76), sugerindo o fator de idade possa predizer os níveis de ansiedade. A análise de regressão múltipla revelou que a idade pode ser um fator significante na análise dos níveis de ansiedade de jogadoras de voleibol (p=0,003; R2=0,82). Estes resultados sugerem que: a) Os níveis de ansiedade traço competitiva apresentaram uma redução significativa após o término da partida que quando comparados na situação pré-competitiva, entretanto, esses níveis ainda são considerados altos segundo os valores de referencia da escala utilizada e; b) Atletas mais jovens apresentam níveis mais altos de ansiedade traço-competitivo, o que permite inferir que esta variável pode ser modulada pela idade e experiência.

The aim of present study was to analyze the levels of competitive anxiety pre and post competitive on volleyball female players and, verify the association between these levels with the age of these athletes. During a competition, 12 female athletes of volleyball with mean of age of 21,5 ± 2,9 (15-24) years answered the Sport Competition Anxiety Test (SCAT) after and immediately before the start of the game. The data were analyzed by non parametric statistics. To verify significant differences on pre and post competition moments were realized a Wilcoxon test. To analyze the association between age and levels of anxiety it was realized the Spearman's correlation and a stepwise multiple regression. The results showed that on post competition moment there was a significant decrease (p=0,01) of competitive anxiety and there is significant correlation (p=0,001; r=0,76) with higher ages and lower levels of competitive anxiety. It suggests that the factor age can predict the levels of anxiety. The multiple regression revealed that the age can be a significant factor on analyze of competitive anxiety of female volleyball players (p=0,003; R2=0,82). These results suggest that: a) Levels of competitive anxiety presented a significant decrease after the end of the game when compared with the begging of the same game; b) Younger athletes presented higher levels of competitive anxiety.