Optic nerve aplasia: A case series

Optic nerve aplasia (ONA) is a congenital optic nerve anomaly characterized by the absence of optic nerve head, retinal blood vessels, retinal ganglion cells, and optic nerve fibers in a malformed eye. Clinically, the condition presents with the absence of perception of light, afferent pupillary defect and a fundus appearance of absent optic nerve head, and retinal vessels with associated ocular and nonocular abnormalities. Systemic anomalies have been reported with bilateral ONA, whereas unilateral ONA is seen in otherwise healthy individuals. We report three cases of ONA with varied clinical presentations.

Ultrasonic studies on molecular interaction of substituted heterocyclic compounds in acetone-water mixture at 303K.

Acoustical and volumetric properties have been measured for substituted heterocyclic compounds drugs and compounds in acetone-water mixture at 303K. The measurement have been perform to evaluate acoustical parameters such as adiabatic compressibility (bs ), Partial molal volume (fv), intermolecular free length (Lf), apparent molal compressibility (fk), specific acoustic impedance (Z), relative association (RA), salvation number (Sn).