Influence of antibiotics on the mechanical responses of guinea-pig ileum to acetycholine and histamine

The side effects of antibiotics have been extensively described during the last decades, however, their role on digestive motility must be better investigated. Following a line research, the influence of penicillin, chloranfenicol tetracycline and gentamicine on longitudinal snooth muscle response to acetylcholine and histamine were studied on guinea-pig ileum. There were no differences between the responses before and after the addition of each antibiotic. Further investigations must be performed in order to find a possible influence of antibiotics on digestive motility.