ABSTRACT
In this research,a new phospholipid based monolith was fabricated by in situ co-polymerization of 1-dodecanoyl-2-(11-methacrylamidoundecanoyl)-sn-glycero-3-phosphoethanolamine and ethylene dimethacrylate to mimick bio-membrane environment.Excellent physicochemical properties of this novel monolith that were achieved included column efficiency,stability,and permeability.Moreover,the biomimetic monolith showed outstanding separation capability for a series of intact proteins and small molecules.In particular,it exhibited good potential as an alternative to the commercial immobilized artificial membrane(IAM)column(IAM.PC.DD2)for studying drug-membrane interactions.This study not only enriched the types of IAM stationary phases,but also provided a simple model for the prediction of phosphatidylethanolamine related properties of drug candidates.
ABSTRACT
Subclinical hypothyroidism (SH) is a category of disease based on laboratory tests, which total or free thyroid hormone is in the normal range, and thyroid-stimulating hormone (TSH) is mild or moderate above normal range disease. With the increasing incidence of subclinical hypothyroidism, the extrathyroidal effect of TSH has got more and more attention. Many studies have shown that adult who suffered SH are often associated with an increased risk of cardiovascular disease, but ignore what contribute to children's health outcomes. However, the problem whether subclinical hypothyroidism would cause adverse health outcomes in children still remains controversial.