ABSTRACT
Objective To compare the clinical effect of montelukast sodium and ketotifen in the treatment of children with cough variant asthma,thus to provide theoretical basis for clinical treatment.Methods 61 children with cough variant asthma were randomly divided into control group and observation group according to the digital table method,31 cases in each group.Patients of two groups were all given antispasmodic and antitussive.The control group was given ketotifen tablets drug therapy,1mg/time,2 times/d,and the observation group was treated with montelukast chewable tablets,5mg/time,1 time /d.After 8 weeks of treatment,the clinical effects were compared between the two groups.Results The total effective rate of the observation group (96.77%)was higher than that of the control group (77.42%),and the difference was statistically significant (χ2 =16.65,P <0.05).The clinical symptoms improved time of the observation group was (5.78 ±1.36)d,which was shorter than (8.45 ±2.24)d of the control group,the difference was statistically significant (t =2.71,P <0.05).The recurrence rate of the observation group (6.45%) was lower than the control group (16.13%),the difference was statistically significant (χ2 =4.67,P <0.05 ). Recurrence time of the observation group was better than that of the control group,the difference was statistically significant (t =7.98,P <0.05 ).Conclusion The curative effect of montelukast special chewing tablets in the treatment of children with bronchial asthma is obviously superior to ketotifen,has less adverse reactions.It was worthy of clinical application.
ABSTRACT
ObjectiveTo explore the relationship between the change of serum lipid and pathological change of coronary artery in Kawasaki disease(KD) children.Methods62 children with pathological change of coronary artery in KD were divided into pathological of coronary artery group and normal coronary artery group.62 normal children were selected as control group in the same time.And then the serum lipid status of three groups were compared.ResultsThe TC (5.32 ± 1.74 ) mmol/L,( 5.24 ± 1.67 ) mmol/L,TG ( 1.67 ± 0.79 ) mmol/L,( 1.74 ± 0.65 ) mmol/L,LDL-C(2.87 ± 1.14 ) mmol/L,( 2.72 ± 1.08 ) mmol/L of KD of the two groups were lower than of the control group(3.08 ± 1.28) mmol/L,( 1.12 ±0.56) mmol/L,(2.37 ± 1.06) mmol/L(t =1.70,1.66,1.71,all P ＜0.05 ),and HDL-C( 1.03 ± 0.31 ) mmol/L,( 1.08 ± 0.57 ) mmol/L higher than that of the control group ( 1.65 ± 0.92 )mmol/L( t =1.54,P ＜ 0.05 ) ; There were no differences between two coronary artery groups.After treated,TC,TG,LDL-C of normal coronary artery group were decreased ( t =1.76,1.88,1.72,all P ＜ 0.05 ),and HDL-C was increased ( t =1.90,P ＜ 0.05 ).ConclusionThe child ren with KD had dyslipidemia,and the dyslipidemia was recovered slowly.So,it should be an index of early diagnose for KD with coronary artery lesion.
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AIM:To investigate effects of thrombopoietin(TPO) and TPOⅡ on human platelet activation in vitro. METHODS:Human platelets were incubated in the phosphate-buffered saline containing rhTPO or TPOⅡ at the concentration of 100 μg/L for five minutes. In order to determine the rate of platelet activation. The CD62P and CD41 expressions on platelets were analysed by flow cytometry using fluorescence labelled monoclonal antibody to CD62P and CD41. RESULTS:The results demonstrated that expression of CD62P on platelets which were incubated with rhTPO or TPOⅡ didn't increase compared with that of contrast group. CONCLUSION:Both rhTPO and TPOⅡdidn't cause the disorder of platelet activation.