ABSTRACT
Objective: To conduct retrospective analysis of clinical features of patients with ulcerative colitis in JiangsuProvince Hospital of Traditional Chinese Medicine (TCM) . Methods: Ulcerative colitis medical records in jiangsuprovince hospital of TCM were selected and used to retrospectively analyze the feature such as gender, age, course of thedisease, clinical type, stage, severity, and pathological parts. Results: The study include 290 cases of male and 235 casesof female with the ratio of 1.2:1. Peak incidence was between 20 to 60 years old. Dietary factor was the most commoncause, followed by fatigue, environment, medicine and emotional factors. There were 28 (5.33％) patients at remissionstage, and 497 (94.67％) patients at active stage. In patients at active stage, there were 78 (15.69％) patients newlydiagnosed, and 419 (84.31％) patients with chronic recurrent type. There 92 (18.51％) rectum type patients, 156 (31.39％) left half colon type patients and 249 (50.10％) extensive colon type patients. There were 275 (55.33％) mild patients, 149 (29.98％) moderate patients and 73 (14.69％) severe patients. The main symptoms were bloody purulent stool, diarrheaand abdominal pain. There were 375 (71.43％) patients with bloody purulent stool, and symptom disappearance rate was89.07％ after treatment. There were 335 (63.81％) patients with diarrhea, and symptom disappearance rate was 71.64％after treatment. There were 319 (60.76％) patients with abdominal pain, and symptom disappearance rate was 85.89％after treatment. There were 3 cases of complications. Drug therapy was mainly based on integrated Chinese and westernmedicine (86.29％) . For Chinese medicine treatment, there were 453 patients (87.45％) with oral Chinese medicine, 401 patients (77.41％) with Chinese medicine enema, and 10 patients (1.93％) with foot bath. For western medicine treatment, there were 392 patients (75.68％) treated with oral amino salicylate drugs, 100 patients (19.31％) with anal used aminosalicylate drugs, 88 patients (16.99％) with glucocorticoid, 18 patients (3.47％) with immunosuppressive agent and 441 patients (85.14％) with microecological preparation. Conclusion: The types of ulcerative colitis patients in our hospitalwere mainly chronic recurrent type at active stage with mild to moderate and extensive colon type. The treatment wasmainly based on integrated Chinese and western medicine, with significant improvement in symptoms of bloody purulentstool, diarrhea and abdominal pain. 99.61％ patients were discharged with a better condition
ABSTRACT
This study was aimed to discover core agent for the treatment of ulcerative colitis and explore the medication rules . A total of 525 ulcerative colitis medical records in the Jiangsu Province Hospital of TCM were selected from 2009 to 2013 . The records were input into the structured information acquisition system of clinical diagnosis and treatment . The complex network analysis was used to analyze core drugs of prescription and drug compatibility after data mining and rule processing . The results showed that the core drugs are Diyu , Huanglian, Muxiang, Baishao, Xianhecao, Danggui, Chaobaizhu, Huangqin, Zicao, Yiyiren, Fuling, Shanyao. It was concluded that data mining can be an objective method in the analysis of core drugs and compatibility in the treatment of ulcerative colitis. It can also be used to guide the clinical prescription medication.