Subject(s)
Adolescent , Adult , Age Factors , Asia , Developing Countries , Female , Humans , Male , Muscular Atrophy, Spinal/diagnosis , Time FactorsABSTRACT
The clinical features and therapeutic aspects of 94 patients with myasthenia gravis seen in the Neurology Institute, General Hospital Colombo, over an eight year period are analysed. The manifestations were similar to that described in the West, but there was a preponderance of male patients, and the ocular myasthenics showed a better response to anticholinesterase medication than described in the world literature. The response to treatment with anticholinesterases, steroids, plasma exchange and thymectomy are assessed.
Subject(s)
Adolescent , Adult , Aged , Child , Child, Preschool , Cholinesterase Inhibitors/therapeutic use , Female , Humans , Infant , Male , Middle Aged , Myasthenia Gravis/diagnosis , Sri Lanka/epidemiologySubject(s)
Adult , Arteriovenous Fistula/diagnosis , Carotid Artery, Internal/surgery , Cavernous Sinus/surgery , Female , Humans , Male , Middle AgedABSTRACT
We report a case of tuberous sclerosis in an 8 year old girl presenting for the first time with features of raised intracranial pressure due to a large intraventricular tumour. Occurrence of these tumours in children with tuberous sclerosis justifies cranial computerised tomography as a screening procedure to detect these tumours early.
Subject(s)
Cerebral Ventricle Neoplasms/complications , Child , Diagnosis, Differential , Ependymoma/complications , Female , Humans , Tomography, X-Ray Computed , Tuberous Sclerosis/complicationsSubject(s)
Adult , Humans , Male , Neurologic Examination/methods , Pain Measurement , Sensation , TemperatureABSTRACT
The percentage protein binding of antiepileptic drugs was investigated in epileptic patients (n = 90) undergoing treatment with phenobarbitone, phenytoin and carbamazepine either as a single drug therapy or in different combinations. When administered individually, the percentage (mean +/- SEM) protein binding of phenobarbitone, phenytoin and carbamazepine were 50.84 +/- 7.03, 87.23 +/- 2.98 and 76.80 +/- 6.30 respectively. Combination of phenobarbitone and phenytoin resulted in percentage (mean +/- SEM) protein binding of 51.94 +/- 6.09 for phenobarbitone and 83.54 +/- 7.01 for phenytoin, while the combination of phenobarbitone and carbamazepine resulted in percentage (mean +/- SEM) protein binding of 49.60 +/- 2.59 for phenobarbitone and 79.10 +/- 3.31 for carbamazepine. When phenytoin was given with carbamazepine percentage (mean +/- SEM) protein binding was 87.22 +/- 4.48 for phenytoin and 72.50 +/- 5.92 for carbamazepine.