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Braz. j. infect. dis ; 10(4): 251-253, Aug. 2006. tab, ilus
Article in English | LILACS | ID: lil-440677

ABSTRACT

Previous analysis of Pseudomonas aeruginosa class-1 integrons from Rio de Janeiro, Brazil, revealed the blaGES gene in one isolate. We screened isolates of two widespread PFGE genotypes, A and B, at a public hospital in Rio, for the presence of blaGES. The gene was detected in all seven P. aeruginosa isolates belonging to genotype B. Three of the seven genotype-B isolates were resistant to amikacin, aztreonam, ceftazidime, cefepime, ciprofloxacin, gentamicin, imipenem, meropenem, piperacillin-tazobactam and ticarcillin-clavulanic acid. The other four isolates were resistant to all these agents, except gentamicin, imipenem, meropenem and piperacillin-tazobactam. A synergistic effect between ceftazidime and imipenem or clavulanic acid suggested the production of GES-type ESBL.


Subject(s)
Humans , Drug Resistance, Multiple, Bacterial/genetics , Pseudomonas aeruginosa/genetics , Anti-Bacterial Agents/pharmacology , Brazil , Drug Synergism , Genotype , Hospitals, Public , Microbial Sensitivity Tests , Pseudomonas Infections/microbiology , Pseudomonas aeruginosa/drug effects , Pseudomonas aeruginosa/isolation & purification , beta-Lactamases/biosynthesis
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