Clinical Efficacy of Radiotherapy Combined with Chemotherapy for Primary Mediastinal Large B-cell Lymphoma / 中国实验血液学杂志

<p><b>OBJECTIVE</b>To explore the clinical efficacy of radiotherapy combined with chemotherapy for patients with primary mediastinal large B-cell lymphoma(PMLBCL).</p><p><b>METHODS</b>A total of 34 cases of PMLBCL were treated by radiotherapy combined with chemotherapy(radio-chemotherapy group), 28 cases of PMLBCL were treated by chemotherapy alone (single chemotherapy group as control). The clinical efficacy, side effects, long-term survival of the two group patients were compared.</p><p><b>RESULTS</b>The overall remission(OR) in the radio-chemotherapy group were higher than that in single chemotherapy group (P<0.05); the blood toxicity reaction, mucositis, radiation dermatitis in radio-chemotherapy group were higher than those in single chemotherapy group (P<0.05); the progress free survival(PFS) for 1 year in radio-chemotherapy group was higher than that in the single chemotherapy group (P<0.05), the local control (LC), PFS for 3 years in the radio-chemotherapy group were higher than those in the single chemotherapy group (P<0.05), the LC, OS, PFS for 5 years in the radio-chemotherapy group were higher than those in the single chemotherapy group (P<0.05).</p><p><b>CONCLUSION</b>The radiotherapy combined with chemotherapy has good clinical efficacy for patients with primary mediastinal large B-cell lymphoma, it has high rate of progression-free survival, it can be used as optimed scheme for treating PMLBCL, but the complications resulting from radio-chemotherapy should be prevented.</p>

Clinical efficacy of radiotherapy and chemotherapy combined with surgical treatment for the patients with primay mediastinal B-cell lymphoma / 中国实验血液学杂志

<p><b>OBJECTIVE</b>This study was to investigate the clinical efficacy of radiotherapy and chemotherapy combined with surgical treatment for treatment of patients with primay mediastinal B-cell lymphoma.</p><p><b>METHODS</b>A total of 62 patients with primay mediastinal B-cell lymphoma was selected, out of them 26 patients received radiotherapy and che-motherapy were selected as A group, other 36 patients received radiotherapy and chemotherapy combined with surgical treatment and were selected as B group. Clinical efficacy were observed and compared after treatment.</p><p><b>RESULTS</b>In A group 5 patients achieved complete remission (CR), 5 patients achieved partial remission (PR), the total remission rate of A group was 27.8%; in B grouop, 13 patients achieved complete remission (CR), 10 patients achieved PR, the total remission rate of B group was 63.9%. The average survival time of patients in B group was 57.244 months, and the average survival time of patients in A group was 55.541 months, the former was higher than latter. The 5 years survical rate of patients in A group was 57.7%, and the 5 years survival rate of patients in B group was 80.6%, the latter was significantly higher than former.</p><p><b>CONCLUSIONS</b>Radiotherapy and chemotherapy combined with surgical treatment for patients with primay media-stinal B-cell lymphoma has been confirmed to be effective, and may be used in clinic.</p>