Endoscopic diagnosis of acute intestinal graft-versus-host disease following allogeneic bone marrow transplantation / 中国实用内科杂志

Objective At present study,we sought to further define the significance of endoscopic and pathological findings in the diagnosis of acute intestinal GVHD.Methods The clinical、endoscopic and pathological data in 23 patients with proven acute intestinal GVHD were retrospectively reviewed.Results The endoscopic features of the ileum and colon varied from being grossly normal、loss of vascular markings、diffuse mucosal erythema、edema and friability to erosion、ulceration、mucosal sloughing and bleeding.Pathological findings included crypt epithelial cell apoptosis and dropout、crypt destruction and variable lymphocytic infiltration of epithelium and lamina propria.Conclusion Endoscopic and pathological evaluation of the ileum and colon can be used to diagnose acute intestinal GVHD.Endoscopy may play a significant role in establishing early diagnosis for acute intestinal GVHD in patients following allogeneic BMT,but pathological evaluation of the ileal and colonic mucosa is needed to confirm the final diagnosis.

Investigation of Relationship Between Helicobacter Pylori Infection and Reflux Esophagitis / 中国医师杂志

Objective To investigate the relationship between helicobacter pylori (H. pylori) infection and reflux esophagitis (RE). Methods H.Pylori infection rates of RE in patients with simple chronic gastritis(CG),which was confirmed by gastrospcope combined with pathological diagnosis were researched.The relationship between HP infection and RE classifications using gastroscope and pathology was explored.Results ⑴H.pylori infection was found in 29(27.1%) in 107 cases of RE and 43(40.2%) in 107 cases of simple CG patients respectively,HP infection positive in RE patients less than that of simple CG patients.RE of class Ⅰ,Ⅱand Ⅲ using gastroscopy classification were 62.1%, 10.3% and 27.6% in H. Pylori-positive cases respectively, while they were 56.4%, 6.4% and 37.2% respectively in H. Pylori-negative ones. However, mild, moderate and severe RE identified by pathohistology were 72.4%, 13.8% and 13.8% in H.Pylori-positive cases respectively, and they were 57.7%, 17.9% and 24.4% respectively in H.Pylori-negative ones.Conclusions All above results suggested that H.Pylori possibly has prevention role in some extent to pathogenesis of RE. RE more commonly was seen in H.Pylori-negative cases.RE could inhibit the H.Pylori survive,So that,the RE was occurred frequently in H.Pylori-negative patients.The inflammatory extent of RE is not serious in H.Pylori-positive patients.