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Article in Portuguese | LILACS | ID: biblio-1359461

ABSTRACT

RESUMO: A resposta inflamatória sistêmica e o déficit nutricional são características frequentes nos pacientes com câncer e o escore prognóstico de Glasgow tem se mostrado excelente valor prognóstico no câncer gastresofágico e ferramenta validada na avaliação clínica de pacientes com câncer. Assim, o presente estudo teve como objetivo analisar a associação do escore prognóstico de Glasgow com sobrevida de pacientes portadores de carcinoma gástrico, através de revisão sistemática e meta-análise. Foi seguida a metodologia Preferred Reporting Items for Systematic Reviews and Meta-Analyses-PRISMA, com pesquisa nas plataformas Medline, Web of Science e SCOPUS, utilizando descritores apropriados. Foram incluídos estudos clínicos e observacionais, publicados antes de 30.09.2017 e sem restrição de linguagem. Os critérios de inclusão foram a utilização do escore prognóstico de Glasgow como fator prognóstico em pacientes portadores de diagnóstico histológico de carcinoma gástrico; com idade superior a 18 anos; submetidos à quimioterapia, radioterapia ou cirurgia; com dosagem de Proteína C Reativa e albumina no pré-tratamento; e com dados referentes à sobrevida durante o estudo. A qualidade dos estudos foi avaliada com a Escala de Newcastle-Ottawa e o risco de viés com ferramenta da Cochrane Collaboration. Hazard-Ratio e Intervalo de Confiança de 95% foram extraídos dos estudos, e a significância estatística definida como p<0,05. Foram identificados 255 artigos, e por fim, analisados 15 estudos. A análise apresentou o escore prognóstico de Glasgow como fator de risco relacionado à sobrevida e considerado marcador prognóstico independente quando relacionado à sobrevida global dos pacientes com câncer gástrico que realizaram cirurgia e quimioterapia. (AU)


ABSTRACT: The systemic inflammatory response and nutritional deficit are frequent features in cancer patients, and the Glasgow prognostic score has shown to be an excellent prognostic value in gastroesophageal cancer and a validated tool in the clinical evaluation of cancer patients. Thus, the present study aimed to analyze the association of Glasgow's prognostic score with the survival of patients with gastric carcinoma through systematic review and meta-analysis. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses-PRISMA methodology was considered, with research on the Medline, Web of Science, and SCOPUS platforms, using appropriate descriptors. Clinical and observational studies published before September 30, 2017, and without language restriction were included. Inclusion criteria were the use of Glasgow prognostic score as a prognostic factor in patients with histological diagnosis of gastric carcinoma; over the age of 18; undergoing chemotherapy, radiation or surgery; with dosages of Reactive Protein C and albumin in the pre-treatment; and with data regarding survival during the study. The quality of the studies was assessed using the Newcastle-Ottawa Scale and the risk of bias using the Cochrane Collaboration tool. Hazard-Ratio and 95% Confidence Interval were extracted from the studies, with statistical significance defined as p <0.05. Two hundred fifty-five articles were identified, and finally, 15 studies were analyzed. The analysis presented Glasgow prognostic score as a risk factor related with survival and considered an independent prognostic marker when related to the overall survival of patients with gastric cancer who underwent surgery and chemotherapy. (AU)


Subject(s)
Humans , Postoperative Complications , Prognosis , Stomach Neoplasms , Survival , Meta-Analysis , Glasgow Outcome Scale
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