Animal models for evaluation of behavior and molecular neurobiological changes with emphasis on spatial memory and cholinergic system impairments in chronic alcohol abuse

In this article we outline the use of experimental animal models to study aspects of memory processes. We describe some results obtained by our group and other laboratories in studies on memory aspects, using rats chronically treated with alcohol. At behavioral and biochemical levels, we focused respectively, on retrograde amnesia and central nervous cholinergic system. We also compare, at both levels, the direct and indirect (those related to thiamine deficiency) effects induced by chronic alcohol treatment.