ABSTRACT
Context: Colorectal cancer (CRC) is one of the most common malignancies and one of the leading causes of cancer death worldwide. Establishing early detection methods or markers of CRC is central to improve the survival rate of CRC patients. Nowadays, new molecular tools have been developed to acquire further knowledge on tumor progression. Aims: Comparative proteomics analysis of Vietnamese colorectal carcinoma in different stages was performed to gain an insight into the molecular events taking place in CRC and metastasis. Subjects and Methods: In this study, the comparative protein expression analysis of ten paired CRC and its corresponding noncancerous tissue samples was performed using the combination of isobaric tags for relative and absolute quantitation labeling and mass spectrometry (MS). The data obtained were further analyzed with Ingenuity Pathways Analysis (IPA) system. Results: Based on the MS/MS spectra analyzed by ProteinPilot software, 684 proteins were identified, out of which 215 were observed to be differentially expressed in at least 1 sample pair. Individual protein expression and variation have been identified for each patient. IPA system demonstrated cytoskeletal signaling as the top-ranked functional pathway network associated with the oncogenic function. Conclusions: Our study supplemented the understanding about proteome of Vietnamese CRC patients and identified statistically protein expression differences among samples assisting in finding effective biomarkers for CRC diagnostics
ABSTRACT
Introduction of 2 new instruments to help improve the quality of endodontics treatment nowadays, it was turning brooch system, especially was protapers and digital tomorgraphy machine. The appearance of Protaper system was a remarkable advantage in endodontics field, having more advantage than older ones such as: more flexible in big brooch, larger tapering helping marrow tube was cleaned and filled in better, the effect of cutting higher, safer in using, completely controlling with touch, decreased ivory crushed in top area, minimum decreased the pressure on brooch and less using brooch, less step, therefore, saving a lots of time. Digital tomorgraphy system was a solution to save tomography time, especially, Visualix USB system was produced by Gendex-Dentsply company. It had more advantage than general tomography system, such as reducing radioactive ray so that it could be put in clinics, no need to darkroom and chemicals, receiving rays by CCD, saving alots of time
Subject(s)
Endodontics , TherapeuticsABSTRACT
To get a better dental care in children, the dentist needs to approach with the dentist who treats for them. This responsibility is belonging to both society and the dentist. A child’s parent knows how to persuade her/his to see the dentist, don’t let them terrify. The parents also should spend more time for their children to help the dentist can give them the better dental care. The dentist must learn more about the children’ psychology and understand their behaviour. Each child has own character and behaviours and they effect from different environment so it is necessary to have the combination of the dentist and other health workers in the dentist’s clinic for a better dental care in children