ABSTRACT
Objective To investigate the influence of magnesium sulfate on C-reactive protein, white blood cells, neutrophils, gastrointestinal function and serum bilirubin levels in patients with acute cholecystitis.Methods 117 patients with acute cholecystitis were randomly divided into two groups (n=60) and control group (n=57).The control group received conventional treatment, and observation group received conventional treatment combined with magnesium sulfate.The leukocyte count and neutrophil percentage, serum total bilirubin and CRP levels, plasma vasoactive intestinal peptide ( VIP) and motilin ( MTL) levels, and disappearance time of fever, abdominal pain, gallbladder enlargement were analysed between two groups of patients.Results After treatment, the leukocyte count and neutrophil percentage of observation group were significantly lower than those before treatment (P<0.05), but there were no significantly differences in above indexes of control group; after treatment, leukocyte count and neutrophil percentage in observation group were significantly lower than those in control group (P<0.05).After treatment, serum CRP and total bilirubin levels in observation group was significantly lower than that before treatment (P<0.05), and CRP level in control group was significantly lower than that before treatment (P<0.05), while total bilirubin level in control group showed no significant change; after treatment, the above indexes in observation group were significantly lower than that in control group (P<0.05).After treatment, plasma VIP levels in both groups was significantly lower than that before treatment, respectively (P<0.05), MTL levels were significantly higher than that before treatment, respectively (P<0.05);after treatment, VIP level was lower, MTL level was higher in observation group than that in control group, respectively (P<0.05).The disappearance time of fever, abdominal pain, gallbladder enlargement in observation group were significantly shorter than that in control group, respectively ( P<0.05 ) .Conclusion The mechanism of magnesium sulfate in the treatment of acute cholecystitis may reduce leukocyte count and neutrophil percentage, serum CRP and total bilirubin, plasma VIP level and increase MTL level.
ABSTRACT
Objective To investigate the expression and clinical significance of connective tissue growth factor(CTGF) in colorectal cancer.Methods The expressions of CTGF in 62 patients' colorectal cancer tissues and their corresponding adjacent tissues were detected by SP immunohistochemical method.The results were statistically analyzed.Results The positive rates of CTGF in colorectal cancer and adjacent tissues were 61.3% and 19.4% respectively,and the difference between them was significant(P0.05).Conclusion CTGF may play an important role in the occurrence of colorectal cancer,which contributes a lot to guide clinical treatment and prognosis.
ABSTRACT
[Objective]To analyze clinical features,evaluate diagnostic procedures and discuss the different forms of therapy for each case of split cord malformation(SCM).[Method]A series of 48 patients had a follow-up period of 0.5~9 years,29 males and 19 females,aged 7 days to 14 years,were evaluated retrospectively.They suffered from back midline abnormalities,neurological deficits of lower limbs and bladder dysfunction.At first they were cut filum terminale and then excised the fibrous or bony spur finally treated scoliosis.The radiologieal procedures used for the diagnosis of SCM were spinal X-ray,ultrasound,CT scan and MRI.[Result]In all of the 48 patients with tethered cord,there were 28 cases with dysplasia of lower limbs and feet,13 cases with urination and defecation dysfunction,14 cases with only dorsal-lumbar abnormalities,26 cases with scoliosis and kyphosis,14 with myelomeningocele,15 with syringomyelia and 12 with intraspinal lipomas.There were 27 cases suffering from type Ⅰ SCM,18 type Ⅱ SCM and 3 composite type SCM according to Pang.The most frequent location of the spur was at the lumbar level(38 cases),the less frequent in thoracic regions(6 cases)and exceptionally rare below S_1(2 cases),in the cervical regions(1 case),the thoralumbar(1 case).After operation,28 cases were improved,3 cases were cured and 3 cases were inefficacy.[Conclusion]The most frequent syndrome of SCM patients is lower limbs dysplasia and dorsal-lumbar abnormalities.The patients are most suffered from tethered cord and spinal deformities.To improve diagnosis of SCM,tethered cord and other deformities,the patients should be routinely evaluated by MRI and X-ray of the whole spine,sometimes could be evaluated by ultrasound and CT scan.SCM cases should be early treated by first cutting filium terminal and then excising fibrous or bony spur and hemivertebra.