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Arq. bras. cardiol ; 56(6): 445-450, jun. 1991. tab
Article in Portuguese | LILACS | ID: lil-107794

ABSTRACT

Purpose - To study the spontaneous variability of single (VPCs) and coupled (CVPCs) in patients with chronic Chagas' disease (CCD). Patients and Methods - Twenty patients with CCD, 14 male, in class I and III NYHA, with frequent VPCs and VCPCs, free of drug therapy were studied.21 hour Holter monitoring was done for 4 subsequent days. The data analysis assessed the variation in the frequency of VPCs and CVPCs between patients, seven hour periods one hour periods in a hierarchical model by a Poisson process. Results - a) the frequency of VPCs follows a circadian rhythm, closely related to the hourly variations of the mean heart rate; b) disregarding the heart rate influence on the variability of the ventricular arrhythmia, its behavior was at random and unpredictable; c) the minimal percentual reduction in VPCs/h that discriminated between antiarrhythmic effect and spontaneous between antiarrhythmic effect and spontaneous variability was 121.86% for sevenhour, 58.42% for 21-hour and 38.45% for 42-hour electrocardiographic monitoring periods; d) the same approch for the VCPCs revealed values of 133,8%, 63.21% and 41.3% respectively


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Chagas Cardiomyopathy/physiopathology , Sleep , Wakefulness , Circadian Rhythm , Electrocardiography , Cardiac Complexes, Premature/physiopathology , Cardiac Complexes, Premature/drug therapy , Analysis of Variance , Anti-Arrhythmia Agents/therapeutic use , Chronic Disease , Heart Rate , Chagas Cardiomyopathy/drug therapy
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