ABSTRACT
PURPOSE: We examined the significance of the CAG repeat polymorphism in the pathogenesis of cryptorchidism. MATERIALS AND METHODS: Genomic deoxyribonucleic acid (DNA) was extracted from blood samples from 42 cryptorchid boys and from 31 non-cryptorchid control subjects. In the cryptorchid group, 7 had bilateral cryptorchidism and 6 had patent processus vaginalis in the contralateral side. To determine the number of CAG repeats, the DNA was amplified by polymerase chain reaction and sequenced. RESULTS: The mean CAG repeat length in the AR gene was 22.5 (range 16 to 28) in patients and 21.5 (range 17 to 26) in controls (non-significant). Patients with bilateral cryptorchidism had a mean length of 24.3 (range 21 to 26) and patients with unilateral cryptorchidism and patent processus vaginalis in the contra lateral side had a mean of 25.2 (range 21 to 28), which was statistically different from controls (p = 0.015 and p = 0.005 respectively). CONCLUSION: CAG repeat length of the AR gene does not seem to play a major role in patients with unilateral cryptorchidism. However, in patients with bilateral undescended testis, a less functional androgen receptor through a longer polyglutamine chain may have a role in its pathogenesis. In the same way, patients with unilateral cryptorchidism a contralateral patent processus vaginalis have longer CAG repeats that might be responsible for a slower testicular descent and incomplete closure of the processus vaginalis.
Subject(s)
Adolescent , Aged , Child , Child, Preschool , Humans , Male , Cryptorchidism/genetics , Polymorphism, Genetic/genetics , Receptors, Androgen/genetics , Trinucleotide Repeats/genetics , Case-Control Studies , Genotype , Polymerase Chain Reaction , Prospective StudiesABSTRACT
O artigo não apresenta resumo.
Subject(s)
Adult , Middle Aged , Humans , Male , Female , Carotid Artery Diseases , Fibromuscular Dysplasia , Neurosurgery , Angiography , Hemiplegia , HyperplasiaSubject(s)
Pregnancy , Adult , Humans , Female , Carotid Artery Diseases , Intracranial Aneurysm , Fibromuscular Dysplasia , NeurosurgerySubject(s)
Middle Aged , Humans , Male , Female , Lasers , Meningioma , Meningeal Neoplasms , Surgical Procedures, OperativeABSTRACT
O presente trabalho faz um estudo de 8 meningiomas retirados de uma serie de 206 tumores de angulo ponto-cerebelar, que sao cotejados com uma breve revisao de literatura, dando enfase ao quadro clinico
Subject(s)
Adult , Middle Aged , Humans , Male , Female , Meningioma , Cerebellopontine AngleSubject(s)
Adult , Humans , Male , Female , Brain Neoplasms , Tomography, X-Ray Computed , Carcinoma, Squamous CellABSTRACT
Os autores apresentam a frequencia dos processos expansivos neoplasicos raque-medulares em numero de 700 casos entre 4.090 casos de processos cirurgicos coletados ate 1980. Sao analisados apenas 579, pois 121 nao tem informacoes histologicas.O material focaliza o enorme numero dos metastaticos e mostra que sem eles a grande maioria dos processos sao benignos
Subject(s)
Humans , Spinal Cord Neoplasms , Neoplasm MetastasisABSTRACT
Os autores realizaram estudo experimental em caes, comparando o comprometimento pulmonar apos injecoes endotraqueais de suco gastrico colhido por sonda nasogastrica, com e sem administracao previa de cimetidine e injecoes de soro fisiologico. Comprovaram alteracoes pulmonares bem mais evidentes e intensidade maior de inflamacao, nos animais em que se injetou suco gastrico sem cimetidine. Concluiram que a cimetidine possui acao protetora contra o dano pulmonar que se estabelece na pneumonia aspirativa