ABSTRACT
Objective To investigate the value of bone turnover markers(BTMs) in forecasting the variance of bone mineral density (BMD) by studying the relationships between BTMs and BMD in persons aged 80 and above.Methods A sample of 1 509 subjects aged 80 and above was recruited.All subjects underwent BMD measurement by dual energy X-ray absorptiometry,and BTMs (C-telopeptide of type 1 collagen,N-terminal propeptide of type 1 procolagen,osteocalcin) measurements.The relationships among all the BTMs,and between BMD and BTMs were analysed.Results In subjects aged 80 and above,the relationships among BTMs were moderately positive(all P＜0.05).In men aged 80 and above,BMDs were inversely associated with BTMs(all P＜0.05),and in women,BMDs were inversely associated with osteocalcin (P＜ 0.05).Conclusions The clinical significance of BTMs in persons aged 80 and above indicates bone resorption when BTMs are raised.In men aged 80 and above any of BTMs may be selected to evaluate bone metabolism ; while in women,osteocalcin should be selected.
ABSTRACT
Objective To find the ways to decrease urinary transferrin(TRF) by analysing its associated factors in aged patients with essential hypertension(EH).Methods A cross-sectional survey was conducted comprising a sample of 617 aged patients with EH.The questionnaire contains items on physical examination,24-h ambulatory blood pressure monitoring,laboratory measurement and TRF measurement. Univariate analyses and multivariate analysis were applied to discover associated factors of TRF.Results Independent associated factors of TRF included the course of EH(OR=1.019,95CI:1.001～1.037,P