ABSTRACT
Although the values reported were higher than those reported for Caucasians, differences in dibucaine number for pseudocholinesterase values among the three ethnic groups in Trinidad and Tobago, were not significant. Eight individuals had intermediate dibucaine numbers values between 40 and 70; one of them was African, 3 were East Indians, and 4 Mixed. Two of the mixed group were of Portuguese lineage and had significantly lower dibucaine numbers and enzyme concentration. Two sisters of East Indian origin had an inestimable dibucaine number and their pseudocholinesterase values were just detectable, suggesting the presence of a 'silent gene' for pseudocholinesterase. These studies, which are being extended, suggest that the dibucaine number should be estimated prior to succinylcholine administration in patients in Trinidad and Tobago who are at risk of apnoea
Subject(s)
Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , /genetics , Dibucaine , Trinidad and Tobago , Racial Groups/geneticsABSTRACT
Dipyrone-induce adverse skin reactions appear within the first seven days of drug administration, and the aetiology is often missed. A patient who regularly consumed dipyrone for dysmenorrhoea is presented. The adverse cutaneous manifestations may be predictive of the occurrence of severe haematological adverse reactions. Adverse drug reactions (ADR) should be documented, and initiation of ADR monitoring units in the Caribbean will be a step in establishing a data base of these events in Caribbean populations
Subject(s)
Adult , Female , Humans , Dipyrone/adverse effects , Dermatitis, Allergic Contact/etiology , Exanthema/etiology , Self Medication/adverse effectsABSTRACT
A document listing drugs, which may be purchased by the Ministry of Health, and containing information on the indications, contraindications, side effects, dosage, and any other special information related to the drug.