1.
Article
in English
| IMSEAR
| ID: sea-177048
ABSTRACT
The endothelium plays a key role in haemostatic balance. Endothelial progenitor cells (EPCs) are involved in the maintenance of endothelial haemostasis and in the process of blood vessel formation. Cardiovascular disease (CVD) is associated with reduced numbers and dysfunction of endothelial cells (ECs) and EPCs. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co-A) reductase helps in restoring of EPCs and improvement of vascular function. This review underlines the pleiotropic effects of atorvastatin on ECs and EPCs.