ABSTRACT
Introduction: Diabetic mellitus is a complex and a diverse group of disorders that disturbs the metabolism of carbohydrates, fat and protein. Plant based medicaments are extensively used for the treatment of various ailments of human beings. The main objective of the present investigation includes the preliminary screening of phytochemicals and evaluation of in vitro antidiabetic efficacy of Physalis angulata fruit extracts. Materials and Methods: Plant material was subjected to sequential extraction by maceration method by using different solvents. Primary screening of the fruit extract was conducted for detection of various types of phytochemicals, whereas antidiabetic activities of Physalis angulata were evaluated using inhibition of alpha amylase and alpha glucosidase enzymes Results: The study reveals the presence of phytochemicals such as alkalodis, saponins, phenols etc. Among the tested extracts of fruit methanol has been successfully inhibited both of the enzymes in vitro. The highest inhibition percentage 97.23 and 96.53 noticed against alpha amylase and alpha glucosidase at 100 μg/ml respectively. The results are comparable with the percentage 95.16% recorded with reference drug acarbose at 10 μg/ml. Conclusion: From the data obtained in the current studies, it was observed that the fruit extracts of Physalis angulata showed prominent antidiabetic properties in vitro and further the studies can be carried out for isolation of active principle responsible for activity.