1.
Indian J Exp Biol
;
1990 Aug; 28(8): 721-3
Article
in English
| IMSEAR
| ID: sea-56281
ABSTRACT
The effect of cyproheptadine (CPH) on glucose tolerance, serum immunoreactive insulin (IRI) and structure of pancreatic islets in albino rats has been studied. Hyperglycemia with glucose intolerance was observed after 10 days of administration of CPH (40 mg/kg, ip). There was insignificant change of fasting IRI after the treatment. Histological studies indicated degranulation and vacuolation of beta cells with enlargement of capillaries. Improvement in blood glucose, glucose tolerance and structure of islets with proliferation of small pancreatic ducts and cell cords were observed 10 days after the withdrawal of CPH.
Subject(s)
Animals , Blood Glucose/analysis , Cyproheptadine/pharmacology , Cytoplasmic Granules/drug effects , Glucose Tolerance Test , Hyperglycemia/chemically induced , Insulin/blood , Islets of Langerhans/drug effects , Male , Rats , Rats, Inbred Strains
2.
Indian J Pediatr
;
1989 Jan-Feb; 56(1): 137-9
Article
in English
| IMSEAR
| ID: sea-80764